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AuthorGupta, Ishita
AuthorRizeq, Balsam
AuthorElkord, Eyad
AuthorVranic, Semir
AuthorAl Moustafa, Ala-Eddin
Available date2020-08-10T08:49:22Z
Publication Date2020-08-05
Publication NameCancers
Identifierhttp://dx.doi.org/10.3390/cancers12082186
CitationGupta, I.; Rizeq, B.; Elkord, E.; Vranic, S.; Al Moustafa, A.-E. SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities. Cancers 2020, 12, 2186.
ISSN2072-6694
URIhttp://hdl.handle.net/10576/15454
AbstractHuman coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied by lung injury, acute respiratory distress syndrome in addition to other organs' destruction. The main impact upon SARS-CoV-2 infection is damage to alveolar and acute respiratory failure. Thus, lung cancer patients are identified as a particularly high-risk group for SARS-CoV-2 infection and its complications. On the other hand, it has been reported that SARS-CoV-2 spike (S) protein binds to angiotensin-converting enzyme 2 (ACE-2), that promotes cellular entry of this virus in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2). Today, there are no vaccines and/or effective drugs against the SARS-CoV-2 coronavirus. Thus, manipulation of key entry genes of this virus especially in lung cancer patients could be one of the best approaches to manage SARS-CoV-2 infection in this group of patients. We herein provide a comprehensive and up-to-date overview of the role of and genes, as key entry elements as well as therapeutic targets for SARS-CoV-2 infection, which can help to better understand the applications and capacities of various remedial approaches for infected individuals, especially those with lung cancer.
SponsorQatar University grants: QUHI-CMED-19/20-1, QUCG-CMED-20/21-2, GCC-2017-002 QU/KU and QUCG-CMED-20/21-2.
Languageen
PublisherMDPI
SubjectACE-2
COVID-19
Coronavirus
SARS-CoV-2
TMPRSS2
inhibitors
lung cancer
TitleSARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.
TypeArticle Review
Issue Number8
Volume Number12
dc.accessType Open Access


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