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المؤلفRaudsepp, Terje
المؤلفChowdhary, Bhanu P.
تاريخ الإتاحة2021-09-08T06:49:48Z
تاريخ النشر2016
اسم المنشورAnnual Review of Animal Biosciences
المصدرScopus
الرقم المعياري الدولي للكتاب21658102
معرّف المصادر الموحدhttp://dx.doi.org/10.1146/annurev-animal-021815-111239
معرّف المصادر الموحدhttp://hdl.handle.net/10576/22941
الملخصThe association between chromosomal abnormalities and reduced fertility in domestic animals is well recorded and has been studied for decades. Chromosome aberrations directly affect meiosis, gametogenesis, and the viability of zygotes and embryos. In some instances, balanced structural rearrangements can be transmitted, causing fertility problems in subsequent generations. Here, we aim to give a comprehensive overview of the current status and future prospects of clinical cytogenetics of animal reproduction by focusing on the advances in molecular cytogenetics during the genomics era. We describe how advancing knowledge about animal genomes has improved our understanding of connections between gross structural or molecular chromosome variations and reproductive disorders. Further, we expand on a key area of reproduction genetics: cytogenetics of animal gametes and embryos. Finally, we describe how traditional cytogenetics is interfacing with advanced genomics approaches, such as array technologies and next-generation sequencing, and speculate about the future prospects. Copyright 2016 by Annual Reviews. All rights reserved.
اللغةen
الناشرAnnual Reviews Inc.
الموضوعCGH
Comparative genomic hybridization
Cytogenetics
Embryos
Gametes
Next-generation sequencing
NGS
Reproduction
العنوانChromosome aberrations and fertility disorders in domestic animals
النوعArticle Review
الصفحات15-43
رقم المجلد4
dc.accessType Abstract Only


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