Show simple item record

AuthorRaudsepp, Terje
AuthorChowdhary, Bhanu P.
Available date2021-09-08T06:49:48Z
Publication Date2016
Publication NameAnnual Review of Animal Biosciences
ResourceScopus
ISSN21658102
URIhttp://dx.doi.org/10.1146/annurev-animal-021815-111239
URIhttp://hdl.handle.net/10576/22941
AbstractThe association between chromosomal abnormalities and reduced fertility in domestic animals is well recorded and has been studied for decades. Chromosome aberrations directly affect meiosis, gametogenesis, and the viability of zygotes and embryos. In some instances, balanced structural rearrangements can be transmitted, causing fertility problems in subsequent generations. Here, we aim to give a comprehensive overview of the current status and future prospects of clinical cytogenetics of animal reproduction by focusing on the advances in molecular cytogenetics during the genomics era. We describe how advancing knowledge about animal genomes has improved our understanding of connections between gross structural or molecular chromosome variations and reproductive disorders. Further, we expand on a key area of reproduction genetics: cytogenetics of animal gametes and embryos. Finally, we describe how traditional cytogenetics is interfacing with advanced genomics approaches, such as array technologies and next-generation sequencing, and speculate about the future prospects. Copyright 2016 by Annual Reviews. All rights reserved.
Languageen
PublisherAnnual Reviews Inc.
SubjectCGH
Comparative genomic hybridization
Cytogenetics
Embryos
Gametes
Next-generation sequencing
NGS
Reproduction
TitleChromosome aberrations and fertility disorders in domestic animals
TypeArticle Review
Pagination15-43
Volume Number4
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record