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المؤلفLaith J., Abu-Raddad
المؤلفChemaitelly, Hiam
المؤلفCoyle, Peter
المؤلفMalek, Joel A.
المؤلفAhmed, Ayeda A.
المؤلفMohamoud, Yasmin A.
المؤلفYounuskunju, Shameem
المؤلفAyoub, Houssein H.
المؤلفAl Kanaani, Zaina
المؤلفAl Kuwari, Einas
المؤلفButt, Adeel A.
المؤلفJeremijenko, Andrew
المؤلفKaleeckal, Anvar Hassan
المؤلفLatif, Ali Nizar
المؤلفShaik, Riyazuddin Mohammad
المؤلفAbdul Rahim, Hanan F.
المؤلفNasrallah, Gheyath K.
المؤلفYassine, Hadi M.
المؤلفAl Kuwari, Mohamed Ghaith
المؤلفAl Romaihi, Hamad Eid
المؤلفAl-Thani, Mohamed H.
المؤلفAl Khal, Abdullatif
المؤلفBertollini, Roberto
تاريخ الإتاحة2021-10-20T08:40:34Z
تاريخ النشر2021-05-31
اسم المنشورEClinicalMedicine
المعرّفhttp://dx.doi.org/10.1016/j.eclinm.2021.100861
الاقتباسAbu-Raddad, L. J., Chemaitelly, H., Coyle, P., Malek, J. A., Ahmed, A. A., Mohamoud, Y. A., ... & Bertollini, R. (2021). SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy. EClinicalMedicine, 35, 100861.
الرقم المعياري الدولي للكتاب25895370
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S2589537021001413
معرّف المصادر الموحدhttp://hdl.handle.net/10576/24583
الملخصBackground Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. SARS-CoV-2 reinfections were assessed in a cohort of antibody-positive persons in Qatar. MethodsAll SARS-CoV-2 antibody-positive persons from April 16 to December 31, 2020 with a PCR-positive swab ≥14 days after the first-positive antibody test were investigated for evidence of reinfection. Viral genome sequencing was conducted for paired viral specimens to confirm reinfection. Incidence of reinfection was compared to incidence of infection in the complement cohort of those who were antibody-negative. FindingsAmong 43,044 antibody-positive persons who were followed for a median of 16.3 weeks (range: 0–34.6), 314 individuals (0.7%) had at least one PCR positive swab ≥14 days after the first-positive antibody test. Of these individuals, 129 (41.1%) had supporting epidemiological evidence for reinfection. Reinfection was next investigated using viral genome sequencing. Applying the viral-genome-sequencing confirmation rate, the incidence rate of reinfection was estimated at 0.66 per 10,000 person-weeks (95% CI: 0.56–0.78). Incidence rate of reinfection versus month of follow-up did not show any evidence of waning of immunity for over seven months of follow-up. Meanwhile, in the complement cohort of 149,923 antibody-negative persons followed for a median of 17.0 weeks (range: 0–45.6), incidence rate of infection was estimated at 13.69 per 10,000 person-weeks (95% CI: 13.22–14.14). Efficacy of natural infection against reinfection was estimated at 95.2% (95% CI: 94.1–96.0%). Reinfections were less severe than primary infections. Only one reinfection was severe, two were moderate, and none were critical or fatal. Most reinfections (66.7%) were diagnosed incidentally through random or routine testing, or through contact tracing. InterpretationReinfection is rare in the young and international population of Qatar. Natural infection appears to elicit strong protection against reinfection with an efficacy ~95% for at least seven months. FundingBiomedical Research Program, the Biostatistics, Epidemiology, and Biomathematics Research Core, and the Genomics Core, all at Weill Cornell Medicine-Qatar, the Ministry of Public Health, Hamad Medical Corporation, and the Qatar Genome Programme.
راعي المشروعThe authors are grateful for support from the Biomedical Research Program, the Biostatistics, Epidemiology, and Biomathematics Research Core, and the Genomics Core, all at Weill Cornell Medicine-Qatar, as well as for support provided by the Ministry of Public Health and Hamad Medical Corporation. The authors are also grateful for support from the Qatar Genome Programme for supporting the viral genome sequencing. The statements made herein are solely the responsibility of the authors.
اللغةen
الناشرElsevier
الموضوعSARS-CoV-2
Epidemiology
Reinfection
Immunity
Genetics
العنوانSARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy
النوعArticle
رقم المجلد35
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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