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المؤلفIftikhar, Khan
المؤلفNeedham, Rachel
المؤلفYousaf, Sakib
المؤلفHouacine, Chahinez
المؤلفIslam, Yamir
المؤلفBnyan, Ruba
المؤلفSadozai, Sajid Khan
المؤلفElrayess, Mohamed A.
المؤلفElhissi, Abdelbary
تاريخ الإتاحة2022-01-09T11:19:04Z
تاريخ النشر2021-12-31
اسم المنشورJournal of Drug Delivery Science and Technology
المعرّفhttp://dx.doi.org/10.1016/j.jddst.2021.102822
الاقتباسIftikhar Khan, Rachel Needham, Sakib Yousaf, Chahinez Houacine, Yamir Islam, Ruba Bnyan, Sajid Khan Sadozai, Mohamed A. Elrayess, Abdelbary Elhissi, Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery, Journal of Drug Delivery Science and Technology, Volume 66, 2021, 102822, ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2021.102822
الرقم المعياري الدولي للكتاب17732247
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1773224721005025
معرّف المصادر الموحدhttp://hdl.handle.net/10576/25632
الملخصThe aim of this study is to formulate and optimize novel transfersome formulations for pulmonary drug delivery. Transfersome formulations (F1 – F18) were prepared by a thin-film method using three phospholipids (Soya phosphatidylcholine (SPC), Dimyristoly phosphatidylcholine (DMPC) and Hydrogenated soya phosphatidylcholine (HSPC)), in combination with three different surfactants (Tween 80, Span 80 and Span 20) with or without cholesterol, employing Beclomethasone dipropionate (BDP) as the model drug. Nano-transfersome formulations post-extrusion were delivered to a Two-stage Impinger (TSI) via three medical nebulizers (i.e. Air-jet, Ultrasonic and Vibrating mesh nebulizer). Based on the physicochemical properties, formulations F1 (SPC and Tween 80), F7 (DMPC and Tween 80) and F13 (HSPC and Tween 80) demonstrated significantly smaller VMD (162.34 ± 6.48, 198.66 ± 6.64, and 183.52 ± 7.34 nm), and significantly higher entrapment efficiency (97.56 ± 2.45, 95.67 ± 4.26 and 95.06 ± 3.38%). Based on nebulization performance, the Ultrasonic nebulizer exhibited the shortest nebulization time for formulations F1, F7 and F13 (i.e. 17.88 ± 2.45, 19.26 ± 2.04 and 19.59 ± 2.12 min), and higher output rate (212.04 ± 11.54, 194.61 ± 10.27 and 192.43 ± 9.84 mg/min), when compared to Air-jet and Vibrating mesh nebulizers. Irrespective of nebulizer type, significantly higher BDP deposition was observed in the lower stage of TSI for the F1 formulation (on average of 61%), whereas a higher amount of BDP was deposited in the upper stage of TSI using the F7 formulations (49%). Moreover, Formulation F1 in combination with Air-jet nebulizer demonstrated higher emitted dose (ED) and fine particle fraction (FPF) (82% and 83%), when compared to the counterpart formulations and nebulizer types investigated. This study has demonstrated that based on nebulizer performance, BDP deposition and formulation type; the F1 formulation in combination with an Air-jet nebulizer is most optimal for lower respiratory tract deposition, whereas the F7 formulation in combination with an Ultrasonic nebulizer is ideal for upper respiratory tract deposition.
اللغةen
الناشرElsevier
الموضوعTransfersome
Nebulizer
Surfactant
Phospholipid
Pulmonary system
Cholesterol
العنوانImpact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery
النوعArticle
رقم المجلد66
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.accessType Open Access


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