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المؤلفSellami, Maha
المؤلفElrayess, Mohamed A
المؤلفPuce, Luca
المؤلفBragazzi, Nicola Luigi
تاريخ الإتاحة2022-01-30T06:20:19Z
تاريخ النشر2022
اسم المنشورFrontiers in Molecular Biosciences
المعرّفhttp://dx.doi.org/10.3389/fmolb.2021.815410
الاقتباسSellami M, Elrayess MA, Puce L and Bragazzi NL (2022) Molecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences. Front. Mol. Biosci. 8:815410. doi: 10.3389/fmolb.2021.815410
معرّف المصادر الموحدhttp://hdl.handle.net/10576/26047
الملخصTogether with environment and experience (that is to say, diet and training), the biological and genetic make-up of an athlete plays a major role in exercise physiology. Sports genomics has shown, indeed, that some DNA single nucleotide polymorphisms (SNPs) can be associated with athlete performance and level (such as elite/world-class athletic status), having an impact on physical activity behavior, endurance, strength, power, speed, flexibility, energetic expenditure, neuromuscular coordination, metabolic and cardio-respiratory fitness, among others, as well as with psychological traits. Athletic phenotype is complex and depends on the combination of different traits and characteristics: as such, it requires a "complex science," like that of metadata and multi-OMICS profiles. Several projects and trials (like ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE) are aimed at discovering genomics-based biomarkers with an adequate predictive power. Sports genomics could enable to optimize and maximize physical performance, as well as it could predict the risk of sports-related injuries. Exercise has a profound impact on proteome too. Proteomics can assess both from a qualitative and quantitative point of view the modifications induced by training. Recently, scholars have assessed the epigenetics changes in athletes. Summarizing, the different omics specialties seem to converge in a unique approach, termed sportomics or athlomics and defined as a "holistic and top-down," "non-hypothesis-driven research on an individual's metabolite changes during sports and exercise" (the Athlome Project Consortium and the Santorini Declaration) Not only sportomics includes metabonomics/metabolomics, but relying on the athlete's biological passport or profile, it would enable the systematic study of sports-induced changes and effects at any level (genome, transcriptome, proteome, etc.). However, the wealth of data is so huge and massive and heterogenous that new computational algorithms and protocols are needed, more computational power is required as well as new strategies for properly and effectively combining and integrating data.
اللغةen
الناشرFrontiers Media
الموضوعOMICS sports sciences
data science
exercise and physical activity
molecular big data
sports medicine
sports sciences
العنوانMolecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences.
النوعArticle
رقم المجلد8
ESSN2296-889X
dc.accessType Open Access


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