Show simple item record

AuthorO. Abbas, Tariq
AuthorA. Ali, Tayyiba
AuthorUddin, Shahab
Available date2022-01-30T08:57:05Z
Publication Date2020-02-26
Publication Namecells
Identifierhttp://dx.doi.org/10.3390/cells9030538
CitationAbbas, T.O.; Ali, T.A.; Uddin, S. Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword. Cells 2020, 9, 538. https://doi.org/10.3390/cells9030538
URIhttp://hdl.handle.net/10576/26095
AbstractIn order to reconstruct injured urinary tract tissues, biodegradable scaffolds with autologous seeded cells are explored in this work. However, when cells are obtained via biopsy from individuals who have damaged organs due to infection, congenital disorders, or cancer, this can result in unhealthy engineered cells and donor site morbidity. Thus, neo-organ construction through an alternative cell source might be useful. Significant advancements in the isolation and utilization of urine-derived stem cells have provided opportunities for this less invasive, limitless, and versatile source of cells to be employed in urologic tissue-engineered replacement. These cells have a high potential to differentiate into urothelial and smooth muscle cells. However, urinary tract reconstruction via tissue engineering is peculiar as it takes place in a milieu of urine that imposes certain risks on the implanted cells and scaffolds as a result of the highly cytotoxic nature of urine and its detrimental effect on both growth and differentiation of these cells. Both of these projections should be tackled thoughtfully when designing a suitable approach for repairing urinary tract defects and applying the needful precautions is vital.
Languageen
Subjecturethra
tissue engineering
cytotoxicity
urinary reconstruction
urothelial cells
TitleUrine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword
TypeArticle
Issue Number3
Volume Number9
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record