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المؤلفAlser, Maha
المؤلفSalman, Huseyin Enes
المؤلفNaïja, Azza
المؤلفSeers, Thomas Daniel
المؤلفKhan, Talha
المؤلفYalcin, Huseyin Cagatay
تاريخ الإتاحة2022-05-10T08:41:30Z
تاريخ النشر2022
اسم المنشورFrontiers in Physiology
المعرّفhttp://dx.doi.org/10.3389/fphys.2022.849603
الاقتباسAlser M, Salman HE, Naïja A, Seers TD, Khan T and Yalcin HC (2022) Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo. Front. Physiol. 13:849603. doi: 10.3389/fphys.2022.849603
معرّف المصادر الموحدhttp://hdl.handle.net/10576/30802
الملخصCollectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart's pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows.
اللغةen
الناشرFrontiers Media
الموضوعchick embryo
computational fluid dynamics
congenital heart defects
hemodynamics
micro-CT
right atrial ligation
ultrasound
ventricle
العنوانBlood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo.
النوعArticle
رقم المجلد13
ESSN1664-042X
dc.accessType Open Access


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