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المؤلفA Elrayess, Mohamed
المؤلفT Zedan, Hadeel
المؤلفA Alattar, Rand
المؤلفAbusriwil, Hatem
المؤلفAl-Ruweidi, Mahmoud Khatib A A
المؤلفAlmuraikhy, Shamma
المؤلفParengal, Jabeed
المؤلفAlhariri, Bassem
المؤلفYassine, Hadi M
المؤلفA Hssain, Ali
المؤلفNair, Arun
المؤلفAl Samawi, Musaed
المؤلفAbdelmajid, Alaaeldin
المؤلفAl Suwaidi, Jassim
المؤلفOmar Saad, Mohamed
المؤلفAl-Maslamani, Muna
المؤلفOmrani, Ali S
المؤلفYalcin, Huseyin C
تاريخ الإتاحة2022-05-16T07:33:24Z
تاريخ النشر2022-12-01
اسم المنشورBlood Pressure
المعرّفhttp://dx.doi.org/10.1080/08037051.2022.2055530
الاقتباسMohamed A. Elrayess, Hadeel T. Zedan, Rand A. Alattar, Hatem Abusriwil, Mahmoud Khatib A. A. Al-Ruweidi, Shamma Almuraikhy, Jabeed Parengal, Bassem Alhariri, Hadi M. Yassine, Ali A. Hssain, Arun Nair, Musaed Al Samawi, Alaaeldin Abdelmajid, Jassim Al Suwaidi, Mohamed Omar Saad, Muna Al-Maslamani, Ali S. Omrani & Huseyin C. Yalcin (2022) Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs, Blood Pressure, 31:1, 80-90, DOI: 10.1080/08037051.2022.2055530
الرقم المعياري الدولي للكتاب0803-7051
معرّف المصادر الموحدhttp://hdl.handle.net/10576/30935
الملخصThis study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients. Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be modulated by antihypertensive drugs such as ACEis and ARBs, which may affect COVID-19's prognosis. BB and CCB reduce mortality, according to some evidence. Their effect on circulating levels of ACE2 and angiotensin II, as well as the severity of COVID-19, is less well studied. The clinical data were collected from 200 patients in four different antihypertensive medication classes (ACEi, ARB, BB, and CCB). Angiotensin II and ACE2 levels were determined using standard ELISA kits. ACE2, angiotensin II, and other clinical indices were evaluated by linear regression models. Patients on ACEi ( = 57), ARB ( = 68), BB ( = 15), or CCB ( = 30) in this study had mild ( = 76), moderate ( = 76), or severe ( = 52) COVID-19. ACE2 levels were higher in COVID-19 patients with severe disease ( = 0.04) than mild ( = 0.07) and moderate ( = 0.007). The length of hospital stay is correlated with ACE2 levels ( = 0.3,  = 0.003). Angiotensin II levels decreased with severity ( = 0.04). Higher ACE2 levels are associated with higher CRP and D-dimer levels. Elevated Angiotensin II was associated with low levels of CRP, D-dimer, and troponin. ACE2 levels increase with disease severity in patients taking an ARB ( = 0.01), patients taking ACEi, the degree of disease severity was associated with a decrease in angiotensin II. BB patients had the lowest disease severity. We found different levels of soluble ACE2, and angiotensin II are observed among COVID-19 patients taking different antihypertensive medications and exhibiting varying levels of disease severity. COVID-19 severity increases with elevated ACE2 levels and lower angiotensin II levels indicating that BB treatment reduces severity regardless of levels of ACE2 and angiotensin II.
راعي المشروعOpen Access funding is provided by the Qatar National Library. This report was made possible by an RRC award [RRC-2-076] from the Qatar National Research Fund (a member of The Qatar Foundation). The statements made herein are solely the responsibility of the authors. We would like to acknowledge Qatar BioBank for helping with the logistics of the collected samples, Prof. Nahla Afifi, Dr. Marwa A. El Deeb, and Ms. Sidra Abdulshakoor. The publication of this paper is covered by Qatar National Library.
اللغةen
الناشرTaylor and Francis
الموضوعACE2
ACEi
Angiotensin II
COVID-19
hypertension
العنوانSoluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs.
النوعArticle
الصفحات80-90
رقم العدد1
رقم المجلد31
ESSN1651-1999
dc.accessType Full Text


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