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AuthorA Elrayess, Mohamed
AuthorT Zedan, Hadeel
AuthorA Alattar, Rand
AuthorAbusriwil, Hatem
AuthorAl-Ruweidi, Mahmoud Khatib A A
AuthorAlmuraikhy, Shamma
AuthorParengal, Jabeed
AuthorAlhariri, Bassem
AuthorYassine, Hadi M
AuthorA Hssain, Ali
AuthorNair, Arun
AuthorAl Samawi, Musaed
AuthorAbdelmajid, Alaaeldin
AuthorAl Suwaidi, Jassim
AuthorOmar Saad, Mohamed
AuthorAl-Maslamani, Muna
AuthorOmrani, Ali S
AuthorYalcin, Huseyin C
Available date2022-05-16T07:33:24Z
Publication Date2022-12-01
Publication NameBlood Pressure
Identifierhttp://dx.doi.org/10.1080/08037051.2022.2055530
CitationMohamed A. Elrayess, Hadeel T. Zedan, Rand A. Alattar, Hatem Abusriwil, Mahmoud Khatib A. A. Al-Ruweidi, Shamma Almuraikhy, Jabeed Parengal, Bassem Alhariri, Hadi M. Yassine, Ali A. Hssain, Arun Nair, Musaed Al Samawi, Alaaeldin Abdelmajid, Jassim Al Suwaidi, Mohamed Omar Saad, Muna Al-Maslamani, Ali S. Omrani & Huseyin C. Yalcin (2022) Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs, Blood Pressure, 31:1, 80-90, DOI: 10.1080/08037051.2022.2055530
ISSN0803-7051
URIhttp://hdl.handle.net/10576/30935
AbstractThis study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients. Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be modulated by antihypertensive drugs such as ACEis and ARBs, which may affect COVID-19's prognosis. BB and CCB reduce mortality, according to some evidence. Their effect on circulating levels of ACE2 and angiotensin II, as well as the severity of COVID-19, is less well studied. The clinical data were collected from 200 patients in four different antihypertensive medication classes (ACEi, ARB, BB, and CCB). Angiotensin II and ACE2 levels were determined using standard ELISA kits. ACE2, angiotensin II, and other clinical indices were evaluated by linear regression models. Patients on ACEi ( = 57), ARB ( = 68), BB ( = 15), or CCB ( = 30) in this study had mild ( = 76), moderate ( = 76), or severe ( = 52) COVID-19. ACE2 levels were higher in COVID-19 patients with severe disease ( = 0.04) than mild ( = 0.07) and moderate ( = 0.007). The length of hospital stay is correlated with ACE2 levels ( = 0.3,  = 0.003). Angiotensin II levels decreased with severity ( = 0.04). Higher ACE2 levels are associated with higher CRP and D-dimer levels. Elevated Angiotensin II was associated with low levels of CRP, D-dimer, and troponin. ACE2 levels increase with disease severity in patients taking an ARB ( = 0.01), patients taking ACEi, the degree of disease severity was associated with a decrease in angiotensin II. BB patients had the lowest disease severity. We found different levels of soluble ACE2, and angiotensin II are observed among COVID-19 patients taking different antihypertensive medications and exhibiting varying levels of disease severity. COVID-19 severity increases with elevated ACE2 levels and lower angiotensin II levels indicating that BB treatment reduces severity regardless of levels of ACE2 and angiotensin II.
SponsorOpen Access funding is provided by the Qatar National Library. This report was made possible by an RRC award [RRC-2-076] from the Qatar National Research Fund (a member of The Qatar Foundation). The statements made herein are solely the responsibility of the authors. We would like to acknowledge Qatar BioBank for helping with the logistics of the collected samples, Prof. Nahla Afifi, Dr. Marwa A. El Deeb, and Ms. Sidra Abdulshakoor. The publication of this paper is covered by Qatar National Library.
Languageen
PublisherTaylor and Francis
SubjectACE2
ACEi
Angiotensin II
COVID-19
hypertension
TitleSoluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs.
TypeArticle
Pagination80-90
Issue Number1
Volume Number31
ESSN1651-1999
dc.accessType Full Text


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