Browsing Medicine Research by Author "Eid, Ali H."
Now showing items 41-60 of 92
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G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon
Fardoun, Manal; Mondello, Stefania; Kobeissy, Firas; Eid, Ali H. ( Frontiers Media , 2022 , Article)Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called Raynaud’s phenomenon (RP). Interestingly, RP is significantly more prevalent in females than age-matched men, highlighting the potential ... -
GPER Acts Through the cAMP/Epac/JNK/AP-1 Pathway to Induce Transcription of Alpha 2C Adrenoceptor in Human Microvascular Smooth Muscle Cells
Fardoun, Manal; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; Eid, Ali H. ( Wolters Kluwer Health , 2023 , Article)Raynaud's phenomenon, which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), ... -
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
Stanley, Ibeh; Bakkar, Nour-Mounira Z.; Ahmad, Fatima; Nwaiwu, Judith; Barsa, Chloe; Mekhjian, Sarine; Reslan, Mohammad Amine; Eid, Ali H.; Harati, Hayat; Nabha, Sanaa; Mechref, Yehia; El-Yazbi, Ahmed F.; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2023 , Article)AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ... -
Hydroxychloroquine in COVID-19 Patients: Pros and Cons
Younis, Nour K.; Zareef, Rana O.; Al Hassan, Sally N.; Bitar, Fadi; Eid, Ali H.; Arabi, Mariam... more authors ... less authors ( Frontiers Media S.A. , 2020 , Article)The pandemic of COVID-19, caused by SARS-CoV-2, has recently overwhelmed medical centers and paralyzed economies. The unparalleled public distress caused by this pandemic mandated an urgent quest for an effective approach ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
Dania, Kattan; Barsa, Chloe; Mekhijian, Sarin; Shakkour, Zaynab; Jammoul, Maya; Doumit, Mark; Zabala, Maria Camila Pareja; Darwiche, Nadine; Eid, Ali H.; Mechref, Yehia; Wang, Kevin K.; de Rivero Vaccari, Juan Pablo; Munoz Pareja, Jennifer C.; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
Eid, Ali H; El-Yazbi, Ahmed F; Zouein, Fouad; Arredouani, Abdelilah; Ouhtit, Allal; Rahman, Md M; Zayed, Hatem; Pintus, Gianfranco; Abou-Saleh, Haissam... more authors ... less authors ( Frontiers Media , 2018 , Article Review)Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ... -
Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration
Al-Saidi, Aya; Alzaim, Ibrahim F.; Hammoud, Safaa H.; Arab, Ghida Al; Abdalla, Samaya; Mougharbil, Nahed; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( Portland Press Ltd , 2024 , Article)The cardiovascular and renovascular complications of metabolic deterioration are associated with localized adipose tissue dysfunction. We have previously demonstrated that metabolic impairment delineated the heightened ... -
Macrophage responses associated with COVID-19: A pharmacological perspective
Booz, George W.; Altara, Raffaele; Eid, Ali H.; Wehbe, Zena; Fares, Souha; Zaraket, Hassan; Habeichi, Nada J.; Zouein, Fouad A.... more authors ... less authors ( Elsevier , 2020 , Article)COVID-19 has caused worldwide death and economic destruction. The pandemic is the result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has demonstrated high rates of infectivity leading to great ... -
Mechanisms underlying the effects of caloric restriction on hypertension
Ahmad A., Al Attar; Fahed, Gracia I.; Hoballah, Malak M.; Pedersen, Shona; El-Yazbi, Ahmed F.; Nasser, Suzanne A.; Bitto, Alessandra; Orekhov, Alexander N.; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional ... -
Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases
Nour K., Younis; Ghoubaira, Joseph A.; Bassil, Emmanuel P.; Tantawi, Houda N.; Eid, Ali H. ( Elsevier , 2021 , Article)Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to ... -
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
Keshavarz, Reyhaneh; Reiner, Željko; Zengin, Gokhan; Eid, Ali H; Sahebkar, Amirhossein ( Europe PM , 2023 , Article)One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ... -
Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris
Jaffa, Aneese A.; Jaffa, Miran A.; Moussa, Mayssam; Ahmed, Ibrahim A.; Karam, Mia; Aldeen, Kawthar Sharaf; Al Sayegh, Rola; El-Achkar, Ghewa A.; Nasrallah, Leila; Yehya, Yara; Habib, Aida; Ziyadeh, Fuad N.; Eid, Ali H.; Kobeissy, Firas H.... more authors ... less authors ( Frontiers Media , 2021 , Article)Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, ... -
Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives
Wedn, Abdalla M.; El-Bassossy, Hany M.; Eid, Ali H.; El-Mas, Mahmoud M. ( Elsevier , 2021 , Article Review)The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune and inflammatory responses under normal and challenged conditions. Over the past two decades, peripheral and central circuits of ... -
Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment
Dwaib, Haneen S.; AlZaim, Ibrahim; Eid, Ali H.; Obeid, Omar; El-Yazbi, Ahmed F. ( Frontiers , 2021 , Article)Cardiometabolic syndrome (CMS) is a cluster of maladaptive cardiovascular, renal, thrombotic, inflammatory, and metabolic disorders. It confers a high risk of cardiovascular mortality and morbidity. CMS is triggered by ... -
Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality
Wehbe, Zena; Hammoud, Safaa Hisham; Yassine, Hadi M; Fardoun, Manal; El-Yazbi, Ahmed F; Eid, Ali H... more authors ... less authors ( Frontiers Media , 2021 , Article)Globally, over two million people have perished due to the recent pandemic caused by SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher rate of severity and mortality in males. Analyzing ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
Posadino, Anna Maria; Erre, Gian Luca; Cossu, Annalisa; Emanueli, Costanza; Eid, Ali H.; Zinellu, Angelo; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Walter de Gruyter , 2022 , Article)Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ... -
Nano-targeting vascular remodeling in cancer: Recent developments and future directions
Roberta, Giordo; Wehbe, Zena; Paliogiannis, Panagiotis; Eid, Ali H.; Mangoni, Arduino A.; Pintus, Gianfranco... more authors ... less authors ( Elsevier , 2022 , Article Review)Tumor growth and progression are strictly dependent on the adequate blood supply of oxygen and nutrients. The formation of new blood vessels and vascular networks is essential to ensure this demand. Blood vessels also ... -
Nanomedicine for Cancer.
Younis, Nour K; Yassine, Hadi M; Eid, Ali H ( Bentham Science Publishers , 2022 , Other)Over the past decades, oncology has occupied the lion’s share of all nanomedical applications [1-3]. In 2020, up to 65% of the clinical trials involving nanomaterials were attending to cancer therapeutics and diagnostics ... -
Nanoparticles: Attractive tools to treat colorectal cancer
Nour K., Younis; Roumieh, Rami; Bassil, Emmanuel P.; Ghoubaira, Joseph A.; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Nasser, Suzanne A.; Baydoun, Serine; Kobeissy, Firas; Shaito, Abdullah; Iratni, Rabah; Muhammad, Khalid; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ...