Browsing Medicine Research by Author "Eid, Ali H."
Now showing items 61-80 of 92
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Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
Shaito, Abdullah; Aramouni, Karl; Assaf, Roland; Parenti, Astrid; Orekhov, Alexander; El Yazbi, Ahmed; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( IMR Press , 2022 , Article Review)Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the ... -
Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations
Ahmadi, Yasin; Fard, Javad Khalili; Ghafoor, Dlzar; Eid, Ali H.; Sahebkar, Amirhossein ( Springer Nature , 2023 , Article)In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported in cancerous ... -
Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations
Summerhill, Volha I.; Sukhorukov, Vasily N.; Eid, Ali H.; Nedosugova, Ludmila V.; Sobenin, Igor A.; Orekhov, Alexander N.... more authors ... less authors ( De Gruyter Open Ltd , 2021 , Article Review)Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement ... -
Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
Hammoud, Safaa H.; AlZaim, Ibrahim; Mougharbil, Nahed; Koubar, Sahar; Eid, Ali H.; Eid, Assaad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( Elsevier , 2021 , Article)Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients’ quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines ... -
Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases
Hammoud, Safaa H.; AlZaim, Ibrahim; Al-Dhaheri, Yusra; Eid, Ali H.; El-Yazbi, Ahmed F. ( Frontiers Media S.A. , 2021 , Article)A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive ... -
The pharmaco-epigenetics of hypertension: a focus on microRNA
Yaacoub, Serge; Boudaka, Ammar; AlKhatib, Ali; Pintus, Gianfranco; Sahebkar, Amirhossein; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Springer Nature , 2024 , Article)Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, ... -
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
Alsamri, Halima; Athamneh, Khawlah; Pintus, Gianfranco; Eid, Ali H.; Iratni, Rabah ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ... -
Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection
Elmarasi, Mohamed; Elmakaty, Ibrahim; Elsayed, Basel; Elsayed, Abdelrahman; Zein, Jana Al; Boudaka, Ammar; Eid, Ali H.... more authors ... less authors ( Wiley-Blackwell , 2024 , Article)Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
Reslan, Mohammad Amine; Issa, Hawraa; Al-Haj, Nadine; Ibeh, Stanley; Yehya, Yara; Hassan, Houssein Hajj; Kobeissy, Firas; Eid, Ali H.; Zibara, Kazem; Shaito, Abdullah; Mohamed, Wael; Yamashita, Toshihide... more authors ... less authors ( Springer Singapore , 2022 , Book chapter)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
Al-Haj, Nadine; Issa, Hawraa; El Zein, Ola; Ibeh, Stanley; Reslan, Mohammad Amine; Yehya, Yara; Kobeissy, Firas; Zibara, Kazem; Eid, Ali H.; Shaito, Abdullah; Mohamed, Wael; Yamashita, Toshihide... more authors ... less authors ( Springer Singapore , 2022 , Book chapter)Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ... -
Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease
Fatemeh, Zahedipour; Butler, Alexandra E.; Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2022 , Article)Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ... -
Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis
Ramli, Iman; Cheriet, Thamere; Posadino, Anna Maria; Giordo, Roberta; Zayed, Hatem; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( IMR Press Limited , 2023 , Article)Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring ... -
Proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside
Mezentsev, Alexandre; Bezsonov, Evgeny; Kashirskikh, Dmitry; Baig, Mirza S.; Eid, Ali H.; Orekhov, Alexander... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)This review summarizes the main achievements in basic and clinical research of atheroscle-rosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of ... -
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
Altabbal, Suhib; Athamnah, Khawla; Rahma, Aaesha; Wali, Adil Farooq; Eid, Ali H.; Iratni, Rabah; Al Dhaheri, Yusra... more authors ... less authors ( MDPI , 2023 , Article)Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ... -
Recent advances in nanotherapeutics for multiple myeloma
Iannazzo, Daniela; Ettari, Roberta; Giofrè, Salvatore; Eid, Ali H.; Bitto, Alessandra ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Anticancer therapies cannot be included in a one-size-fits-all scenario; it is imperative to adapt therapies to the tumor molecular profile and most importantly to develop target-specific therapeutics. Nanotherapeutics can ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
Shaito, Abdullah; Al-Mansoob, Maryam; Ahmad, Salma M S; Haider, Mohammad Z; Eid, Ali H; Posadino, Anna Maria; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ... -
Retinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics
El-Baba, Chirine; Eid, Ali H.; Shaito, Abdallah; Kobeissy, Firas; Darwiche, Nadine ( Springer Nature , 2022 , Book chapter)Retinoids are a large family of structurally related natural and synthetic molecules that exhibit a variety of effects in embryogenesis and adult life. The parent compound of retinoids is vitamin A which was first discovered ... -
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Tedy, Sawma; Shaito, Abdullah; Najm, Nicolas; Sidani, Munir; Orekhov, Alexander; El-Yazbi, Ahmed F.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
Dwaib, Haneen S.; AlZaim, Ibrahim; Ajouz, Ghina; Eid, Ali H.; El-Yazbi, Ahmed ( American Society for Pharmacology and Experimental Therapy (ASPET) , 2022 , Article)The evolving view of gut microbiota has shifted toward describing the colonic flora as a dynamic organ in continuous interaction with systemic physiologic processes. Alterations of the normal gut bacterial profile, known ... -
Synthesis of New Chromene Derivatives Targeting Triple-Negative Breast Cancer Cells
Alneyadi, Aysha; Nizami, Zohra N.; Aburawi, Hanan E.; Hisaindee, Soleiman; Nawaz, Muhammad; Attoub, Samir; Ramadan, Gaber; Benhalilou, Nehla; Al Azzani, Mazoun; Elmahi, Yassine; Almeqbali, Aysha; Muhammad, Khalid; Eid, Ali H.; Vijayan, Ranjit; Iratni, Rabah... more authors ... less authors ( MDPI , 2023 , Article)Breast cancer continues to be the leading cause of cancer-related deaths among women worldwide. The most aggressive type of breast cancer is triple-negative breast cancer (TNBC). Indeed, not only does TNBC not respond well ...