Browsing Medicine Research by Author "Habib, Aida"
Now showing items 1-5 of 5
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The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model
Firas, Kobeissy; Mallah, Khalil; Zibara, Kazem; Dakroub, Fatima; Dalloul, Zeinab; Nasser, Mohammad; Nasrallah, Leila; Mallah, Zahraa; El-Achkar, Ghewa A.; Ramadan, Naify; Mohamed, Wael; Mondello, Stefania; Darwish, Hala; Hamade, Eva; Habib, Aida... more authors ... less authors ( Elsevier , 2022 , Article)Traumatic Brain Injury (TBI) is one of the leading causes of death and disability worldwide. Aspirin (ASA) and clopidogrel (CLOP) are antiplatelet agents that inhibit platelet aggregation. They are implicated in worsening ... -
Effect of very long-term storage and multiple freeze and thaw cycles on 11-dehydro-thromboxane-B(2) and 8-iso-prostaglandin F(2α,) levels in human urine samples by validated enzyme immunoassays
Petrucci, Giovanna; Hatem, Duaa; Langley, Ruth; Cleary, Siobhan; Gentry-Maharaj, Aleksandra; Pitocco, Dario; Rizzi, Alessandro; Ranalli, Paola; Zaccardi, Francesco; Habib, Aida; Rocca, Bianca... more authors ... less authors ( Springer Nature , 2024 , Article)Biological samples are often frozen and stored for years and/or thawed multiple times, thus assessing their stability on long-term storage and repeated freeze–thaw cycles is crucial. The study aims were to assess:—the ... -
Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris
Jaffa, Aneese A.; Jaffa, Miran A.; Moussa, Mayssam; Ahmed, Ibrahim A.; Karam, Mia; Aldeen, Kawthar Sharaf; Al Sayegh, Rola; El-Achkar, Ghewa A.; Nasrallah, Leila; Yehya, Yara; Habib, Aida; Ziyadeh, Fuad N.; Eid, Ali H.; Kobeissy, Firas H.... more authors ... less authors ( Frontiers Media , 2021 , Article)Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, ... -
Platelet thromboxane inhibition by low-dose aspirin in polycythemia vera: Ex vivo and in vivo measurements and in silico simulation
Petrucci, Giovanna; Giaretta, Alberto; Ranalli, Paola; Cavalca, Viviana; Dragani, Alfredo; Porro, Benedetta; Hatem, Duaa; Habib, Aida; Tremoli, Elena; Patrono, Carlo; Rocca, Bianca... more authors ... less authors ( Wiley , 2022 , Article)Low-dose aspirin is currently recommended for patients with polycythemia vera (PV), a myeloproliferative neoplasm with increased risk of arterial and venous thromboses. Based on aspirin pharmacodynamics in essential ... -
Thromboxane biosynthesis and future events in diabetes: the ASCEND trial
Petrucci, Giovanna; Buck, Georgina A.; Rocca, Bianca; Parish, Sarah; Baigent, Colin; Hatem, Duaa; Mafham, Marion; Habib, Aida; Bowman, Louise; Armitage, Jane; Patrono, Carlo... more authors ... less authors ( Oxford University Press , 2024 , Article)Background and Thromboxane (TX) A2, released by activated platelets, plays an important role in atherothrombosis. Urinary 11-dehydro-Aims TXB2 (U-TXM), a stable metabolite reflecting the whole-body TXA2 biosynthesis, is ...