Browsing Medicine Research by Author "Rabbani, Naila"
Now showing items 1-20 of 21
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AGEomics Biomarkers and Machine Learning—Realizing the Potential of Protein Glycation in Clinical Diagnostics
Rabbani, Naila ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Protein damage by glycation, oxidation and nitration is a continuous process in the physiological system caused by reactive metabolites associated with dicarbonyl stress, oxidative stress and nitrative stress, respectively. ... -
Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease
Rabbani, Naila; Adaikalakoteswari, Antonysunil; Larkin, James R.; Panagiotopoulos, Sianna; MacIsaac, Richard J.; Yue, Dennis K.; Fulcher, Gregory R.; Roberts, Matthew A.; Thomas, Merlin; Ekinci, Elif; Thornalley, Paul J.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Accumulation of advanced glycation endproducts (AGEs) is linked to decline in renal function, particularly in patients with diabetes. Major forms of AGEs in serum are protein-bound AGEs and AGE free adducts. In this study, ... -
Antiviral activity of glucose-derived reactive metabolite, methylglyoxal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
AlKhatib, Hebah A M; ElBashir, Israa; Yassine, Hadi M.; Thornalley, Paul J; Rabbani, Naila ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in a global health emergency. With incomplete vaccination and incomplete protection of the vaccinated population, there remains an urgent ... -
Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Jinit, Masania; Wijten, Patrick; Keipert, Susanne; Ost, Mario; Klaus, Susanne; Rabbani, Naila; Thornalley, Paul J.... more authors ... less authors ( Elsevier , 2023 , Article)Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing ... -
Dicarbonyl stress, protein glycation and the unfolded protein response
Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J. ( Springer , 2021 , Article Review)The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. ... -
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
Rabbani, Naila; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. Increased MG glycation produces ... -
Evaluation of antiviral activity of Manuka honey against SARS-CoV-2.
Elbashir, Israa; Aisha Nasser J M Al-Saei, Aisha; Thornalley, Paul; Rabbani, Naila ( Qatar University Press , 2021 , Poster)Background and aims: In 2020 a global pandemic was declared caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The pandemic is still ongoing and continues to cause considerable mortality and morbidity ... -
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
Ashour, Amal; Xue, Mingzhan; Al-Motawa, Maryam; Thornalley, Paul J.; Rabbani, Naila ( BMJ Publishing Group , 2020 , Article)Introduction Patients with diabetes have increased risk of periodontal disease, with increased risk of weakening of periodontal ligament and tooth loss. Periodontal ligament is produced and maintained by periodontal ligament ... -
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ... -
High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes
Perkins, B.A.; Perkins, Bruce A.; Rabbani, Naila; Weston, Andrew; Adaikalakoteswari, Antonysunil; Lee, Justin A.; Lovblom, Leif E.; Cardinez, Nancy; Thornalley, Paul J.... more authors ... less authors ( Nature Publishing Group , 2020 , Article)Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephropathy. We reported levels of serum protein glycation, oxidation and nitration and related hydrolysis products, glycation, ... -
Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response
Xue, Mingzhan; Irshad, Zehra; Rabbani, Naila; Thornalley, Paul J. ( Elsevier B.V. , 2024 , Article)The unfolded protein response (UPR) detects increased misfolded proteins and activates protein refolding, protein degradation and inflammatory responses. UPR sensors in the endoplasmic reticulum, IRE1α and PERK, bind and ... -
An Introduction to the Special Issue “Protein Glycation in Food, Nutrition, Health and Disease”
Rabbani, Naila; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Other)On 20–24 September 2021, leading researchers in the field of glycation met online at the 14th International Symposium on the Maillard Reaction (IMARS-14), hosted by the authors of this introductory editorial, who are from ... -
A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.
Rowan, Sheldon; Jiang, Shuhong; Chang, Min-Lee; Volkin, Jonathan; Cassalman, Christa; Smith, Kelsey M; Streeter, Matthew D; Spiegel, David A; Moreira-Neto, Carlos; Rabbani, Naila; Thornalley, Paul J; Smith, Donald E; Waheed, Nadia K; Taylor, Allen... more authors ... less authors ( Elsevier , 2020 , Article)Age-related macular degeneration (AMD) is a major blinding disease, affecting over 14% of the elderly. Risk for AMD is related to age, diet, environment, and genetics. Dietary modulation of AMD risk is a promising treatment ... -
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes
Rabbani, Naila ( Portland Press Ltd , 2022 , Article)The study of the glyoxalase system by Thornalley and co-workers in clinical diabetes mellitus and correlation with diabetic complications revealed increased exposure of patients with diabetes to the reactive, dicarbonyl ... -
Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes.
Feskens, Edith; Brennan, Lorraine; Dussort, Pierre; Flourakis, Matthieu; Lindner, Lena M E; Mela, David; Rabbani, Naila; Rathmann, Wolfgang; Respondek, Frédérique; Stehouwer, Coen; Theis, Stephan; Thornalley, Paul; Vinoy, Sophie... more authors ... less authors ( Oxford University Press , 2020 , Article)There is considerable interest in dietary and other approaches to maintaining blood glucose concentrations within the normal range and minimizing exposure to postprandial hyperglycemic excursions. The accepted marker to ... -
Protein Glycation in Plants-An Under-Researched Field with Much Still to Discover.
Rabbani, Naila; Al-Motawa, Maryam; Thornalley, Paul J ( MDPI , 2020 , Article)Recent research has identified glycation as a non-enzymatic post-translational modification of proteins in plants with a potential contributory role to the functional impairment of the plant proteome. Reducing sugars with ... -
Reading patterns of proteome damage by glycation, oxidation and nitration: quantitation by stable isotopic dilution analysis LC-MS/M
Rabbani, Naila; Thornalley, Paul J. ( Portland Press , 2020 , Article Review)Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides a high sensitivity, high specificity multiplexed method for concurrent detection of adducts formed by protein glycation, oxidation and nitration, also ... -
Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination—link to dysglycemia, blood pressure, dyslipidemia, and low-grade inflammation
Rabbani, Naila; Xue, Mingzhan; Weickert, Martin O.; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)The dietary supplement, trans-resveratrol and hesperetin combination (tRES-HESP), induces expression of glyoxalase 1, countering the accumulation of reactive dicarbonyl glycating agent, methylglyoxal (MG), in overweight ... -
Risk prediction of early decline in renal function in diabetic kidney disease with algorithm including fractional excretion of glycated amino acids
Rabbani, Naila; de a Fuente, Alberto; Thornalley, Paul ( Qatar University Press , 2021 , Poster)Background and aims: Diabetic kidney disease occurs in ca. 40% patients with diabetes. Approximately 1 in 5 patients with type 1 diabetes mellitus (T1DM) and 1 in 3 patients with type 2 diabetes mellitus (T2DM) develop ... -
Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome
Alhujaily, Muhanad; Abbas, Hafsa; Xue, Mingzhan; de la Fuente, Alberto; Rabbani, Naila; Thornalley, Paul J.... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ...