Medicine Research: Recent submissions
Now showing items 701-720 of 1508
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The Association Between Inflammatory Bowel Disease and Exposure to Tobacco Smoking: A Case-Control Study in Qatar
( Dove Medical Press , 2023 , Article)Objective: This research investigated the association between childhood and adulthood tobacco smoking exposure with ulcerative colitis (UC) and Crohn’s disease (CD) in Qatar. Study Design and Setting: In this case-control ... -
The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection
( Frontiers Media , 2023 , Article)Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ... -
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
( MDPI , 2023 , Article)Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ... -
Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study
( Dave Medical Press Limited, , 2023 , Article)Aim: We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar. Methods: ... -
Validation of Doi's weighted average glucose as a measure of post-load glucose excursion for clinical use.
( Biomolecules and Biomedicine , 2023 , Article)In this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
( Elsevier , 2023 , Article Review)Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ... -
Sickness absenteeism among primary health care workers in Qatar before and during the COVID-19 pandemic
( BioMed Central Ltd , 2023 , Article)Objectives: To explore the patterns, trends, nature, and extent of changes in sickness absence among health care workers (HCWs) at the Primary Health Care Corporation (PHCC) in Qatar-during the COVID-19 pandemic compared ... -
The Arabic Questionnaire for Psychotic Experiences in patients with psychotic disorders: a clinical validation
( BioMed Central Ltd , 2023 , Article)Background: Psychotic experiences are reported in the general population. The Questionnaire for Psychotic Experiences (QPE) was created to test the phenomenological features of these experiences and compare them with those ... -
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
( BioMed Central Ltd , 2023 , Article)Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ... -
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
( Nature Research , 2023 , Article)Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ... -
Applications of Machine Learning in Chronic Myeloid Leukemia
( MDPI , 2023 , Article)Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by dysregulated growth and the proliferation of myeloid cells in the bone marrow caused by the BCR-ABL1 fusion gene. Clinically, CML demonstrates ... -
Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study
( Taylor and Francis Ltd. , 2023 , Article)Purpose: Low bicarbonate, a hallmark of metabolic acidosis is associated with various diseases. This study investigated associations between bicarbonate levels with prediabetes and subclinical inflammation among healthy ... -
The impact of prior obesity surgery on glucose metabolism after body contouring surgery: A pilot study.
( Europe PMC , 2023 , Article)Body contouring surgery enhances physical appearance by means of surgical subcutaneous fat removal (SSFR). However, it remains unclear how SSFR may affect glucose metabolism and its broader effects on the endocrine system, ... -
ANO4 Expression Is a Potential Prognostic Biomarker in Non-Metastasized Clear Cell Renal Cell Carcinoma
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Background: Over the past decade, transcriptome profiling has elucidated many pivotal pathways involved in oncogenesis. However, a detailed comprehensive map of tumorigenesis remains an enigma to solve. Propelled research ... -
Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis
( Frontiers Media S.A. , 2023 , Article)Background and objectives: Polypharmacy and chronic kidney disease (CKD) are becoming increasingly common due to an ageing population and the rise of multimorbidity. In line with the therapeutic guidelines, managing CKD ... -
Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials.
( BioMed Central , 2023 , Article)Triple-Negative Breast Cancer (TNBC) is a lethal subtype of breast cancer with limited treatment options. The purpose of this Network Meta-Analysis (NMA) is to compare the efficacy and safety of inhibitors of programmed ... -
Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III.
( Europe PMC , 2023 , Article)Mucopolysaccharidosis type III (MPS III) is a rare autosomal recessive lysosomal storage disease (LSD) caused by a deficiency of lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs), mainly in the ... -
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
( Europe PM , 2023 , Article)One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ... -
How can we improve the measurement of receptor signaling bias?
( Taylor & Francis Group , 2023 , Article)G protein-coupled receptors (GPCRs) are flexible and dynamic signaling entities that can adopt multiple active conformations upon activation [Citation1,Citation2]. However, each agonist stabilizes a distinct receptor ... -
Epidemiology of herpes simplex virus type 2 in the Middle East and North Africa: Systematic review, meta-analyses, and meta-regressions
( Wiley-Blackwell , 2023 , Article)Herpes simplex virus type 2 (HSV-2) infection is a prevalent, sexually transmitted infection with poorly characterized prevalence in the Middle East and North Africa (MENA) region. This study characterized HSV-2 epidemiology ...
