Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections.
| Author | Qassim, Suelen H |
| Author | Chemaitelly, Hiam |
| Author | Ayoub, Houssein H |
| Author | AlMukdad, Sawsan |
| Author | Tang, Patrick |
| Author | Hasan, Mohammad R |
| Author | Yassine, Hadi M |
| Author | Al-Khatib, Hebah A |
| Author | Smatti, Maria K |
| Author | Abdul-Rahim, Hanan F |
| Author | Nasrallah, Gheyath K |
| Author | Al-Kuwari, Mohamed Ghaith |
| Author | Al-Khal, Abdullatif |
| Author | Coyle, Peter |
| Author | Kaleeckal, Anvar Hassan |
| Author | Shaik, Riyazuddin Mohammad |
| Author | Latif, Ali Nizar |
| Author | Al-Kuwari, Einas |
| Author | Jeremijenko, Andrew |
| Author | Butt, Adeel A |
| Author | Bertollini, Roberto |
| Author | Al-Romaihi, Hamad Eid |
| Author | Al-Thani, Mohamed H |
| Author | Abu-Raddad, Laith J |
| Available date | 2022-06-12T04:57:12Z |
| Publication Date | 2022-05-27 |
| Publication Name | Journal of Travel Medicine (JTM) |
| Identifier | http://dx.doi.org/10.1093/jtm/taac068 |
| Citation | Suelen H Qassim, MBBS MPH, Hiam Chemaitelly, PhD, Houssein H Ayoub, PhD, Sawsan AlMukdad, MSc, Patrick Tang, MD PhD, Mohammad R Hasan, PhD, Hadi M Yassine, PhD, Hebah A Al-Khatib, PhD, Maria K Smatti, MSc, Hanan F Abdul-Rahim, PhD, Gheyath K Nasrallah, PhD, Mohamed Ghaith Al-Kuwari, MD, Abdullatif Al-Khal, MD, Peter Coyle, MD, Anvar Hassan Kaleeckal, MSc, Riyazuddin Mohammad Shaik, MSc, Ali Nizar Latif, MD, Einas Al-Kuwari, MD, Andrew Jeremijenko, MD, Adeel A Butt, MBBS MS, Roberto Bertollini, MD MPH, Hamad Eid Al-Romaihi, MD, Mohamed H Al-Thani, MD, Laith J Abu-Raddad, PhD, Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections, Journal of Travel Medicine, 2022;, taac068, https://doi.org/10.1093/jtm/taac068 |
| ISSN | 1708-8305 |
| Abstract | Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value-3.53 fewer cycles (95% CI: 3.46-3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of infection for BA.2. Natural immunity from previous infection and booster vaccination were associated with less infectious breakthrough infections. |
| Sponsor | The authors are grateful for support from the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, as well as for support provided by the Ministry of Public Health, Hamad Medical Corporation, and Sidra Medicine. The authors are also grateful for the Qatar Genome Programme and Qatar University Biomedical Research Center for institutional support for the reagents needed for the viral genome sequencing. Statements made herein are solely the responsibility of the authors. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the Article |
| Language | en |
| Publisher | Oxford University Press |
| Subject | COVID-19 Omicron breakthrough infection cohort study epidemiology immunity sub-lineage subvariant vaccine |
| Type | Article |
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