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AuthorChemaitelly, Hiam
AuthorAyoub, Houssein H
AuthorAlMukdad, Sawsan
AuthorCoyle, Peter
AuthorTang, Patrick
AuthorYassine, Hadi M
AuthorAl-Khatib, Hebah A
AuthorSmatti, Maria K
AuthorHasan, Mohammad R
AuthorAl-Kanaani, Zaina
AuthorAl-Kuwari, Einas
AuthorJeremijenko, Andrew
AuthorKaleeckal, Anvar Hassan
AuthorLatif, Ali Nizar
AuthorShaik, Riyazuddin Mohammad
AuthorAbdul-Rahim, Hanan F
AuthorNasrallah, Gheyath K
AuthorAl-Kuwari, Mohamed Ghaith
AuthorButt, Adeel A
AuthorAl-Romaihi, Hamad Eid
AuthorAl-Thani, Mohamed H
AuthorAl-Khal, Abdullatif
AuthorBertollini, Roberto
AuthorAbu-Raddad, Laith J
Available date2022-06-12T10:19:34Z
Publication Date2022-06-02
Publication Namenature communications
Identifierhttp://dx.doi.org/10.1038/s41467-022-30895-3
CitationChemaitelly, H., Ayoub, H.H., AlMukdad, S. et al. Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar. Nat Commun 13, 3082 (2022). https://doi.org/10.1038/s41467-022-30895-3
URIhttp://hdl.handle.net/10576/32084
AbstractSARS-CoV-2 Omicron BA.1 and BA.2 subvariants are genetically divergent. We conducted a matched, test-negative, case-control study to estimate duration of protection of the second and third/booster doses of mRNA COVID-19 vaccines against BA.1 and BA.2 infections in Qatar. BNT162b2 effectiveness was highest at 46.6% (95% CI: 33.4-57.2%) against symptomatic BA.1 and at 51.7% (95% CI: 43.2-58.9%) against symptomatic BA.2 infections in the first three months after the second dose, but declined to ~10% or below thereafter. Effectiveness rebounded to 59.9% (95% CI: 51.2-67.0%) and 43.7% (95% CI: 36.5-50.0%), respectively, in the first month after the booster dose, before declining again. Effectiveness against COVID-19 hospitalization and death was 70-80% after the second dose and >90% after the booster dose. mRNA-1273 vaccine protection showed similar patterns. mRNA vaccines provide comparable, moderate, and short-lived protection against symptomatic BA.1 and BA.2 Omicron infections, but strong and durable protection against COVID-19 hospitalization and death.
SponsorWe acknowledge the many dedicated individuals at Hamad Medical Corporation, the Ministry of Public Health, the Primary Health Care Corporation, the Qatar Biobank, Sidra Medicine, and Weill Cornell Medicine—Qatar for their diligent efforts and contributions to make this study possible. The authors are grateful for support from the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, as well as for support provided by the Ministry of Public Health, Hamad Medical Corporation, and Sidra Medicine. The authors are also grateful for the Qatar Genome Program and Qatar University Biomedical Research Center for institutional support for the reagents needed for the viral genome sequencing. Statements made herein are solely the responsibility of the authors. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the article.
Languageen
PublisherNature Research
SubjectEpidemiology
Viral infection
TitleDuration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar.
TypeArticle
ESSN2041-1723
dc.accessType Open Access


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