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المؤلفChemaitelly, Hiam
المؤلفAyoub, Houssein H.
المؤلفCoyle, Peter
المؤلفTang, Patrick
المؤلفYassine, Hadi M.
المؤلفAl-Khatib, Hebah A.
المؤلفSmatti, Maria K.
المؤلفHasan, Mohammad R.
المؤلفAl-Kanaani, Zaina
المؤلفAl-Kuwari, Einas
المؤلفJeremijenko, Andrew
المؤلفKaleeckal, Anvar Hassan
المؤلفLatif, Ali Nizar
المؤلفShaik, Riyazuddin Mohammad
المؤلفAbdul-Rahim, Hanan F.
المؤلفNasrallah, Gheyath K.
المؤلفAl-Kuwari, Mohamed Ghaith
المؤلفButt, Adeel A.
المؤلفAl-Romaihi, Hamad Eid
المؤلفAl-Thani, Mohamed H.
المؤلفAl-Khal, Abdullatif
المؤلفBertollini, Roberto
المؤلفAbu-Raddad, Laith J.
تاريخ الإتاحة2022-08-21T07:03:45Z
تاريخ النشر2022-12-01
اسم المنشورNature Communications
المعرّفhttp://dx.doi.org/10.1038/s41467-022-32363-4
الاقتباسChemaitelly, H., Ayoub, H.H., Coyle, P. et al. Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage. Nat Commun 13, 4675 (2022). https://doi.org/10.1038/s41467-022-32363-4
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135731078&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/33279
الملخصThere is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other sub-lineage in Qatar during a large BA.1 and BA.2 Omicron wave, from December 19, 2021 to March 21, 2022. Two national matched, retrospective cohort studies are conducted to estimate effectiveness of BA.1 infection against reinfection with BA.2 (N = 20,994; BA.1-against-BA.2 study), and effectiveness of BA.2 infection against reinfection with BA.1 (N = 110,315; BA.2-against-BA.1 study). Associations are estimated using Cox proportional-hazards regression models after multiple imputation to assign a sub-lineage status for cases with no sub-lineage status (using probabilities based on the test date). Effectiveness of BA.1 infection against reinfection with BA.2 is estimated at 94.2% (95% CI: 89.2–96.9%). Effectiveness of BA.2 infection against reinfection with BA.1 is estimated at 80.9% (95% CI: 73.1–86.4%). Infection with the BA.1 sub-lineage appears to induce strong, but not full immune protection against reinfection with the BA.2 sub-lineage, and vice versa, for at least several weeks after the initial infection.
اللغةen
الناشرNature Research
الموضوعEpidemiology
SARS-CoV-2
Viral infection
العنوانProtection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage
النوعArticle
رقم العدد1
رقم المجلد13
ESSN2041-1723
dc.accessType Open Access


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