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AuthorChemaitelly, Hiam
AuthorAyoub, Houssein H.
AuthorCoyle, Peter
AuthorTang, Patrick
AuthorYassine, Hadi M.
AuthorAl-Khatib, Hebah A.
AuthorSmatti, Maria K.
AuthorHasan, Mohammad R.
AuthorAl-Kanaani, Zaina
AuthorAl-Kuwari, Einas
AuthorJeremijenko, Andrew
AuthorKaleeckal, Anvar Hassan
AuthorLatif, Ali Nizar
AuthorShaik, Riyazuddin Mohammad
AuthorAbdul-Rahim, Hanan F.
AuthorNasrallah, Gheyath K.
AuthorAl-Kuwari, Mohamed Ghaith
AuthorButt, Adeel A.
AuthorAl-Romaihi, Hamad Eid
AuthorAl-Thani, Mohamed H.
AuthorAl-Khal, Abdullatif
AuthorBertollini, Roberto
AuthorAbu-Raddad, Laith J.
Available date2022-08-21T07:03:45Z
Publication Date2022-12-01
Publication NameNature Communications
Identifierhttp://dx.doi.org/10.1038/s41467-022-32363-4
CitationChemaitelly, H., Ayoub, H.H., Coyle, P. et al. Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage. Nat Commun 13, 4675 (2022). https://doi.org/10.1038/s41467-022-32363-4
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135731078&origin=inward
URIhttp://hdl.handle.net/10576/33279
AbstractThere is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other sub-lineage in Qatar during a large BA.1 and BA.2 Omicron wave, from December 19, 2021 to March 21, 2022. Two national matched, retrospective cohort studies are conducted to estimate effectiveness of BA.1 infection against reinfection with BA.2 (N = 20,994; BA.1-against-BA.2 study), and effectiveness of BA.2 infection against reinfection with BA.1 (N = 110,315; BA.2-against-BA.1 study). Associations are estimated using Cox proportional-hazards regression models after multiple imputation to assign a sub-lineage status for cases with no sub-lineage status (using probabilities based on the test date). Effectiveness of BA.1 infection against reinfection with BA.2 is estimated at 94.2% (95% CI: 89.2–96.9%). Effectiveness of BA.2 infection against reinfection with BA.1 is estimated at 80.9% (95% CI: 73.1–86.4%). Infection with the BA.1 sub-lineage appears to induce strong, but not full immune protection against reinfection with the BA.2 sub-lineage, and vice versa, for at least several weeks after the initial infection.
Languageen
PublisherNature Research
SubjectEpidemiology
SARS-CoV-2
Viral infection
TitleProtection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage
TypeArticle
Issue Number1
Volume Number13
ESSN2041-1723
dc.accessType Open Access


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