Show simple item record

AuthorMesmar, Joelle
AuthorAbdallah, Rola
AuthorBadran, Adnan
AuthorMaresca, Marc
AuthorShaito, Abdullah
AuthorBaydoun, Elias
Available date2022-08-23T05:21:37Z
Publication Date2022-07-01
Publication NameMolecules
Identifierhttp://dx.doi.org/10.3390/molecules27134240
CitationMesmar J, Abdallah R, Badran A, Maresca M, Shaito A, Baydoun E. Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties. Molecules. 2022 Jun 30;27(13):4240. doi: 10.3390/molecules27134240.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134425857&origin=inward
URIhttp://hdl.handle.net/10576/33342
AbstractZiziphus nummularia, a small bush of the Rhamnaceae family, has been widely used in traditional folk medicine, is rich in bioactive molecules, and has many reported pharmacological and therapeutic properties. Objective: To gather the current knowledge related to the medicinal characteristics of Z. nummularia. Specifically, its phytochemical contents and pharmacological activities in the treatment of various diseases such as cancer, diabetes, and cardiovascular diseases, are discussed. Methods: Major scientific literature databases, including PubMed, Scopus, ScienceDirect, SciFinder, Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, Henriette′s Herbal Homepage, Dr. Duke′s Phytochemical and Ethnobotanical Databases, were searched to retrieve articles related to the review subject. General web searches using Google and Google scholar were also utilized. The search period covered articles published between 1980 and the end of October 2021.The search used the keywords ‘Ziziphus nummularia’, AND (‘phytochemical content’, ‘pharmacological properties, or activities, or effects, or roles’, ‘anti-inflammatory’, ‘anti-drought’, ‘anti-thermal’, ‘anthelmintic’, ‘antidiabetic’,’ anticancer’, ‘anticholinesterase’, ‘antimicrobial’, ‘sedative’, ‘antipyretic’, ‘analgesic’, or ‘gastrointestinal’). Results: This plant is rich in characteristic alkaloids, especially cyclopeptide alkaloids such as nummularine-M. Other phytochemicals, including flavonoids, saponins, glycosides, tannins, and phenolic compounds, are also present. These phytochemicals are responsible for the reported pharmacological properties of Z. nummularia, including anti-inflammatory, antioxidant, antimicrobial, anthelmintic, antidiabetic, anticancer, analgesic, and gastrointestinal activities. In addition, Z. nummularia has anti-drought and anti-thermal characteristics. Conclusion: Research into the phytochemical and pharmacological properties of Z. nummularia has demonstrated that this plant is a rich source of novel bioactive compounds. So far, Z. nummularia has shown a varied pharmacological profile (antioxidant, anticancer, anti-inflammatory, and cardioprotective), warranting further research to uncover the therapeutic potential of the bioactives of this plant. Taken together, Z. nummularia may represent a new potential target for the discovery of new drug leads.
SponsorThe authors would like to thank the URB of the American University of Beirut and the University of Petra for their funding
Languageen
PublisherMDPI
Subjectanti-inflammatory
antioxidant
cyclopeptide alkaloids
nummularine-M
phytochemicals
Ziziphus nummularia
TitleZiziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties
TypeArticle Review
Issue Number13
Volume Number27
ESSN1420-3049
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record