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المؤلفAbdul Q., Khan
المؤلفAl-Tamimi, Maha
المؤلفUddin, Shahab
المؤلفSteinhoff, Martin
تاريخ الإتاحة2022-12-29T05:28:56Z
تاريخ النشر2021-12-31
اسم المنشورDrug Discovery Today
المعرّفhttp://dx.doi.org/10.1016/j.drudis.2021.07.006
الرقم المعياري الدولي للكتاب13596446
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1359644621003147
معرّف المصادر الموحدhttp://hdl.handle.net/10576/37765
الملخصCancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, disease relapse, and therapeutic resistance. Hence, it is imperative to explore how progenitor or cancer-initiating cells acquire stemness features and reprogram different biological mechanisms to maintain their sustained oncogenicity. Interestingly, deregulation of F-box proteins (FBPs) is crucial for cancer stemness features, including drug resistance and disease relapse. In this review, we highlight recent updates on the clinical significance of targeting FBPs in cancer therapy, with emphasis on eliminating CSCs and associated therapeutic challenges. Moreover, we also discuss novel strategies for the selective elimination of CSCs by targeting FBPs.
راعي المشروعThis work was supported by IRGC-04-NI-17-155, IRGC-06-NI-19-189, and MRC-01-18-186, grants funded by the Medical Research Center (MRC), Hamad Medical Corporation, Doha, State of Qatar. The authors acknowledge open access funding provided by the Qatar National Library.
اللغةen
الناشرElsevier
الموضوعF-box proteins and signaling
Cancer pathogenesis
Cancer stem cells
Stemness
Poor clinical outcomes
العنوانF-box proteins in cancer stemness: An emerging prognostic and therapeutic target
النوعArticle
الصفحات2905-2914
رقم العدد12
رقم المجلد26
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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