عرض بسيط للتسجيلة

المؤلفYousaf, Sakib Saleem
المؤلفIsreb, Abdullah
المؤلفKhan, Iftikhar
المؤلفMewsiga, Enosh
المؤلفElhissi, Abdelbary
المؤلفAhmed, Waqar
المؤلفAlhnan, Mohamed A.
تاريخ الإتاحة2023-02-28T10:10:26Z
تاريخ النشر2021
اسم المنشورPharmaceutical Development and Technology
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1080/10837450.2021.1931886
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40534
الملخصAqueous-based film coating suspensions are associated with reliance on alkalinising reagents and poor film formation. The impact of particle size in this process and resultant film properties remains unclear. This study offers the first direct comparison of film formation properties between aqueous micro- and nano-suspensions of the enteric polymer Eudragit S100. High-pressure homogenisation was employed to produce nano-suspensions of the enteric polymer. Formed enteric suspensions (micro- and nano-) were evaluated in terms of size, morphology, and ability to form film; with resultant films analysed in terms of; film thickness, mechanical and thermoplastic properties, water uptake, weight loss, and drug permeability in acidic medium. High-pressure homogenisation yielded particles within a submicron range (150–200 nm). Produced nano-suspensions formed significantly thinner films (p < 0.01), at lower plasticiser concentrations, than films cast from micro-suspensions (differences in thickness up to 100 µm); however, exhibited comparative gastro-resistant properties (p > 0.05) in terms of water uptake (∼25% w/w), weight loss (<16% w/w) and drug permeability (<0.1%). Interestingly, nano-suspension-based films exhibited lower glass transition temperatures (Tg) (p < 0.01), when compared to films cast from micro-suspensions (∼7–20 °C difference), indicating enhanced plasticisation. This was reflected in film mechanical properties; where nano-suspension-based films demonstrated significantly lower tensile strength (p < 0.01) and higher percentage elongation (p < 0.05), suggesting high elasticity. Thinner, highly elastic films were formed from nano-suspensions, compared to films cast from micro-suspensions, exhibiting comparative properties; obviating the need for alkalinising agents and high concentrations of plasticiser.
راعي المشروعOpen Access funding provided by the Qatar National Library.
اللغةen
الناشرTaylor and Francis Ltd.
الموضوعdosage unit
environmentally friendly
green
methacrylate
Nanotechnology
polymeric
العنوانImpact of nanosizing on the formation and characteristics of polymethacrylate films: micro- versus nano-suspensions
النوعArticle
الصفحات729-739
رقم العدد7
رقم المجلد26
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة