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AuthorSaberianpour, Shirin
AuthorAbolbashari, Samaneh
AuthorModaghegh, Mohamad H.S.
AuthorKarimian, Maryam S.
AuthorEid, Ali H.
AuthorSathyapalan, Thozhukat
AuthorSahebkar, Amirhossein
Available date2023-03-27T07:44:57Z
Publication Date2022-08-01
Publication NameJournal of Cellular Biochemistry
Identifierhttp://dx.doi.org/10.1002/jcb.30309
CitationSaberianpour, S, Abolbashari, S, Modaghegh, MHS, et al. Therapeutic effects of statins on osteoarthritis: a review. J Cell Biochem. 2022; 123: 1285- 1297. doi:10.1002/jcb.30309
ISSN07302312
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134945158&origin=inward
URIhttp://hdl.handle.net/10576/41334
AbstractOsteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. Hypercholesterolemia is considered a novel risk factor for the development of OA. Statins act as a competitive inhibitor of the β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase and are widely used to manage hypercholesterolemia. Inhibition of HMG-CoA reductase results in reduced synthesis of a metabolite named mevalonate, thereby reducing cholesterol biosynthesis in subsequent steps. By this mechanism, statins such as atorvastatin and simvastatin could potentially have a preventive impact on joint cartilage experiencing osteoarthritic deterioration by reducing serum cholesterol levels. Atorvastatin can protect cartilage degradation following interleukin-1β-stimulation. Atorvastatin stimulates the STAT1-caspase-3 signaling pathway that was shown to be responsible for its anti-inflammatory effects on the knee joint. Simvastatin had chondroprotective effects on OA in vitro by reducing matrix metalloproteinases expression patterns. In this study, we tried to review the therapeutic effects of statins on OA.
Languageen
PublisherWiley
Subjectosteoarthritis
statins
therapy
TitleTherapeutic effects of statins on osteoarthritis: A review
TypeArticle Review
Pagination1285 - 1297
Issue Number8
Volume Number123
ESSN1097-4644
dc.accessType Abstract Only


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