عرض بسيط للتسجيلة

المؤلفGiordo, Roberta
المؤلفCossu, Annalisa
المؤلفPorcu, Maria Cristina
المؤلفCappuccinelli, Roberto
المؤلفBiosa, Grazia
المؤلفSharifi-Rad, Javad
المؤلفPretti, Luca
المؤلفNasrallah, Gheyath K.
المؤلفPintus, Gianfranco
المؤلفPosadino, Anna Maria
تاريخ الإتاحة2023-03-29T10:18:37Z
تاريخ النشر2022-10-06
اسم المنشورNatural Product Research
المعرّفhttp://dx.doi.org/10.1080/14786419.2022.2130304
الاقتباسGiordo, R., Cossu, A., Porcu, M. C., Cappuccinelli, R., Biosa, G., Sharifi-Rad, J., ... & Posadino, A. M. (2022). Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells. Natural Product Research, 1-7.
الرقم المعياري الدولي للكتاب1478-6419
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139548890&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/41422
الملخصGreen chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition and biological effects of a leaves Pistacia lentiscus L. supercritical carbon dioxide (SCCO2) extract. Terpenes represented the main extract fraction, with Germacrene D (11.18%), delta-cadinene (10.54%), and alpha-pinene (8.7%) the most abundant molecules. Challenged with endothelial cells (ECs), increasing extract concentrations failed to affect cell proliferation or promote cell toxicity. ROS assessment in unstressed and H2O2-treated ECs revealed an extract dose-dependent antioxidant activity. Exposition of H2O2-treated ECs to increasing extract concentrations dose-dependently counteracted H2O2-induced cell impairments. The extract significantly counteracted fetal calf serum-induced ECs migration. For the first time, we report that a SCCO2 extract obtained from PL leaves is safe on ECs and may be a useful source of valuable compounds with vasculoprotective properties.
راعي المشروعOpen Access funding was provided by the Qatar National Library.
اللغةen
الناشرTaylor & Francis
الموضوعantioxidants
cardiovascular diseases
endothelial cells
Pistacia lentiscus
reactive oxygen species
supercritical CO 2
العنوانCytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
النوعArticle
الصفحات1-7
ESSN1478-6427
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة