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AuthorGiordo, Roberta
AuthorCossu, Annalisa
AuthorPorcu, Maria Cristina
AuthorCappuccinelli, Roberto
AuthorBiosa, Grazia
AuthorSharifi-Rad, Javad
AuthorPretti, Luca
AuthorNasrallah, Gheyath K.
AuthorPintus, Gianfranco
AuthorPosadino, Anna Maria
Available date2023-03-29T10:18:37Z
Publication Date2022-10-06
Publication NameNatural Product Research
Identifierhttp://dx.doi.org/10.1080/14786419.2022.2130304
CitationGiordo, R., Cossu, A., Porcu, M. C., Cappuccinelli, R., Biosa, G., Sharifi-Rad, J., ... & Posadino, A. M. (2022). Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells. Natural Product Research, 1-7.
ISSN1478-6419
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139548890&origin=inward
URIhttp://hdl.handle.net/10576/41422
AbstractGreen chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition and biological effects of a leaves Pistacia lentiscus L. supercritical carbon dioxide (SCCO2) extract. Terpenes represented the main extract fraction, with Germacrene D (11.18%), delta-cadinene (10.54%), and alpha-pinene (8.7%) the most abundant molecules. Challenged with endothelial cells (ECs), increasing extract concentrations failed to affect cell proliferation or promote cell toxicity. ROS assessment in unstressed and H2O2-treated ECs revealed an extract dose-dependent antioxidant activity. Exposition of H2O2-treated ECs to increasing extract concentrations dose-dependently counteracted H2O2-induced cell impairments. The extract significantly counteracted fetal calf serum-induced ECs migration. For the first time, we report that a SCCO2 extract obtained from PL leaves is safe on ECs and may be a useful source of valuable compounds with vasculoprotective properties.
SponsorOpen Access funding was provided by the Qatar National Library.
Languageen
PublisherTaylor & Francis
Subjectantioxidants
cardiovascular diseases
endothelial cells
Pistacia lentiscus
reactive oxygen species
supercritical CO 2
TitleCytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
TypeArticle
Pagination1-7
ESSN1478-6427
dc.accessType Open Access


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