السجلات المعروضة 121 -- 140 من 1673

    • Flavonoids, gut microbiota and cardiovascular disease: Dynamics and interplay 

      Mansour, Hadi; Slika, Hasan; Nasser, Suzanne A.; Pintus, Gianfranco; Khachab, Maha; ... more authors ( Elsevier , 2024 , Article Review)
      Cardiovascular disease (CVD) remains the leading cause of global morbidity and mortality. Extensive efforts have been invested to explicate mechanisms implicated in the onset and progression of CVD. Besides the usual ...
    • Effects of dietary curcumin on gene expression: An analysis of transcriptomic data in mice 

      Mahjoubin-Tehran, Maryam; Hasan, Ammar; Eid, Ali H.; Almahmeed, Wael; Kesharwani, Prashant; ... more authors ( Elsevier , 2024 , Article Review)
      BACKGROUND: Curcumin, a ubiquitous polyphenol in turmeric, possesses many anti-cancer and anti-inflammatory properties. These therapeutic effects are largely resultant of curcumin's ability to modulate global gene expression. ...
    • Hypospadias risk associated with chronic hypertension during pregnancy: A systematic review and meta-analysis 

      Situmorang, Gerhard Reinaldi; Hasan; Wahyudi, Irfan; Abbas, Tariq; Rodjani, Arry; ... more authors ( Elsevier , 2024 , Article Review)
      Introduction: Previous studies have suggested that hypertensive disorders of pregnancy increase risk of hypospadias, but so far none have focused on the influence of maternal chronic hypertension (CH). This study aimed to ...
    • Burden of disease scenarios by state in the USA, 2022–50: a forecasting analysis for the Global Burden of Disease Study 2021 

      Ali H, Mokdad; Bisignano, Catherine; Hsu, Johnathan M; Bryazka, Dana; Cao, Shujin; ... more authors ( Elsevier , 2024 , Article)
      BackgroundThe capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. ...
    • Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 

      Hmwe Hmwe, Kyu; Vongpradith, Avina; Dominguez, Regina-Mae Villanueva; Ma, Jianing; Albertson, Samuel B; ... more authors ( Elsevier , 2024 , Article)
      BackgroundDiarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age ...
    • National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050 

      Marie, Ng; Dai, Xiaochen; Cogen, Rebecca M; Abdelmasseh, Michael; Abdollahi, Arash; ... more authors ( Elsevier , 2024 , Article)
      BackgroundOver the past several decades, the overweight and obesity epidemic in the USA has resulted in a significant health and economic burden. Understanding current trends and future trajectories at both national and ...
    • Exploring student perceptions on virtual reality in anatomy education: insights on enjoyment, effectiveness, and preferences. 

      Al-Hor, Mohammed; Almahdi, Hamad; Al-Theyab, Majed; Mustafa, Ayman G; Seed Ahmed, Mohammed; ... more authors ( Springer Nature , 2024 , Article)
      The dynamic landscape of medical education demands innovative teaching methods. This study introduces virtual reality (VR) technology to anatomy courses at Qatar University, aiming to assess students' receptiveness to ...
    • Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration 

      Traidl-Hoffmann, Claudia; Afghani, Jamie; Akdis, Cezmi A.; Akdis, Mübecel; Aydin, Handan; ... more authors ( John Wiley and Sons , 2024 , Article)
      The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high ...
    • Modified transanal minimally invasive surgery procedure for an ultralow rectal lesion—A video vignette 

      Kurer, Mohamed; Toffaha, Ali; Abu Nada, Mohamed; Al Dhaheri, Mahmood ( John Wiley and Sons , 2024 , Other)
      Management of rectal lesions, benign or malignant, has evolved with the improvement of surgical tools and techniques. Total mesorectal excision (TME) and proctectomy remain the gold standard curative procedures [1, 2]. ...
    • Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Michael, Brauer; Roth, Gregory A; Aravkin, Aleksandr Y; Zheng, Peng; Abate, Kalkidan Hassen; ... more authors ( Elsevier Ltd. , 2024 , Article)
      Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to ...
    • Atopic dermatitis: A global health perspective 

      Faye, Ousmane; Flohr, Carsten; Kabashima, Kenji; Ma, Lin; Paller, Amy S.; ... more authors ( John Wiley and Sons , 2023 , Article)
      The International Society of AD (ISAD) organized a roundtable on global aspects of AD at the WCD 2023 in Singapore. According to the Global Burden of Disease (GBD) consortium, at least 171 million individuals were affected ...
    • Retrospective evaluation of a TEN/SJS series managed with a new treatment protocol 

      Steinhoff, Martin; Buddenkotte, Joerg; Al-Shafi, Wadha; Al-Marri, Hissa; Emam, Fatima; ... more authors ( John Wiley and Sons , 2024 , Other)
      Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening diseases without standardized treatment. The mortality rate ranges from 20% to 50%, and can reach up to 90%, based on the ...
    • Severe atopic dermatitis in an Asian-Arabic population treated with dupilumab: A retrospective observational study 

      Al Chalabi, Radi; Sherbash, Mohamed; Al-Marri, Fahad; Iqneibi, Mariam; Joy, Febu Elizabeth; ... more authors ( John Wiley and Sons , 2024 , Other)
      Atopic dermatitis (AD) is a common, inflammatory skin disease characterized by a TH2-deviated immune response in the acute phase and a TH2/TH1/TH17/TH22-skewed immune response in the chronic phase1 associated with pruritus. ...
    • Cytochrome P450 Enzymes: The Old Pandora's Box with an Ever-Growing Hope for Therapy Optimization and Drug Development-Editorial 

      El-Yazbi, Ahmed F.; Eid, Ali H. ( American Society for Pharmacology and Experimental Therapy (ASPET) , 2024 , Other)
      In 1841, the notion of drug metabolism in the body was coined with the discovery of hippuric acid as a metabolite of benzoic acid in urine of human subjects (Ure, 1841). Since then, there has been an explosive growth in ...
    • Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T-cell lymphoma cells treated with Glabridin 

      Khan, Abdul Q.; Agha, Maha Victor; Ahmad, Fareed; Anver, Rasheeda; Sheikhan, Khalid Sultan A.M.; ... more authors ( John Wiley and Sons , 2024 , Article)
      Cutaneous T-cell lymphomas (CTC) are a heterogeneous group of T-cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in ...
    • Successful treatment of pachyonychia congenita with simvastatin 

      Iqneibi, Mariam; Al-Khawaga, Sara; Wafi, Omar; Steinhoff, Martin ( John Wiley and Sons , 2023 , Other)
      Pachyonychia congenita (PC) is a rare autosomal-dominant genodermatosis. It is an ectodermal, dysplastic disorder of keratinization that typically arises at birth or early infancy due to keratin-specific gene mutations, ...
    • Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway 

      Patil, Kalyani; Khan, Abdul Q.; Ahmad, Fareed; Kuttikrishnan, Shilpa; Anver, Rasheeda; ... more authors ( IMR Press Limited , 2024 , Article)
      Background: The benzophenanthridine Sanguinarine (Sng) is one of the most abundant root alkaloids with a long history of investigation and pharmaceutical applications. The cytotoxicity of Sng against various tumor cells ...
    • A practical guide to the management of immune thrombocytopenia co-existing with acute coronary syndrome 

      Rahhal, A.; Provan, Drew; Ghanima, Waleed; González-López, Tomás José; Shunnar, Khaled; ... more authors ( Frontiers Media SA , 2024 , Article Review)
      Introduction: Immune thrombocytopenia (ITP) management with co-existing acute coronary syndrome (ACS) remains challenging as it requires a clinically relevant balance between the risk and outcomes of thrombosis and the ...
    • Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype 

      Ansari, Abdul Wahid; Jayakumar, Manju Nidagodu; Ahmad, Fareed; Venkatachalam, Thenmozhi; Salameh, Laila; ... more authors ( Frontiers Media SA , 2024 , Article)
      Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the ...
    • A prospective cohort study on cognitive and psychological outcomes in COVID-19 ICU survivors at 3 months of follow up 

      Thomas, Merlin; Hameed, Mansoor; Hussein, Mousa; George, Saibu; Rajalekshmi, M. R.; ... more authors ( Frontiers Media SA , 2024 , Article)
      Objective: The Outcomes – Short and Long term in ICU patient with COVID-19 “OUTSTRIP COVID-19” study was initiated to assess overall mortality, physical and psychiatric co-morbidities, reduction in lung function, and the ...