College of Medicine: Recent submissions
Now showing items 141-160 of 1537
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Kv7 Channel Activators Flupirtine and ML213 Alleviate Neuropathic Pain Behavior in the Streptozotocin Rat Model of Diabetic Neuropathy
( Dove Press Ltd , 2024 , Article)Background & Objective: Chronic peripheral neuropathic pain (PNP) is a debilitating condition that is associated with many types of injury/diseases, including diabetes mellitus. Patients with longstanding diabetes develop ... -
Adrenoceptor Desensitization: Current Understanding of Mechanisms
( The American Society for Pharmacology and Experimental Therapeutics , 2024 , Article Review)G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biologic functions including vision, olfaction, chemotaxis, and immunity. However, as essential ... -
Tumor-type agnostic, targeted therapies make a new step forward: The first tumor-agnostic approval of a HER2-targeted therapy
( the Association of Basic Medical Sciences , 2024 , Article)Oncologic treatment has recently undergone substantial therapeutic paradigm shifts, from classical tumor-specific and biomarker-agnostic approaches to more molecular, biomarker-specific, and tumor-agnostic. Tumor-type ... -
Proteomic Analysis of Prehypertensive and Hypertensive Patients: Exploring the Role of the Actin Cytoskeleton
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Hypertension is a pervasive and widespread health condition that poses a significant risk factor for cardiovascular disease, which includes conditions such as heart attack, stroke, and heart failure. Despite its widespread ... -
Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health
( Springer , 2024 , Article Review)Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has ... -
Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Obesity, characterized by excessive body fat, is closely linked to endoplasmic reticulum (ER) stress, leading to insulin resistance and type 2 diabetes. Inflammatory pathways like c-Jun N-terminal kinase (JNK) worsen insulin ... -
Association between Serum Vitamin D Status and Circadian Syndrome: A Cross-Sectional Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: Circadian Syndrome (CircS) encompasses cardiometabolic risk factors and comorbidities, indicating an elevated susceptibility to cardiovascular disease and type 2 diabetes. Methods: This cross-sectional study ... -
Metabolomics Profiling of Stages of Coronary Artery Disease Progression
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are ... -
Undesirable Levels of Practice Behaviours and Associated Knowledge amongst Community Health Workers in Rural South India Responsible for Type 2 Diabetes Screening and Management
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: Type 2 diabetes (T2DM) poses an enormous global health care challenge, especially among rural communities. Healthcare in these areas can be inadequate and inaccessible due to socio-demographic barriers. To ... -
Enhanced vasorin signaling mitigates adverse cardiovascular remodeling
( John Wiley and Sons Inc , 2024 , Article Review)Arterial stiffening is a critical risk factor contributing to the exponential rise in age-associated cardiovascular disease incidence. This process involves age-induced arterial proinflammation, collagen deposition, and ... -
Angiotensin receptor blocker-neprilysin inhibitor for heart failure with reduced ejection fraction
( Elsevier , 2024 , Article Review)Heart failure with reduced ejection fraction (HFrEF) is a clinical syndrome characterized by volume overload, impaired exercise capacity, and recurrent hospital admissions. A major contributor to the pathophysiology and ... -
CAR-T cell therapy: Efficacy in management of cancers, adverse effects, dose-limiting toxicities and long-term follow up
( Elsevier , 2024 , Article Review)Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as a groundbreaking and highly promising approach for the management of cancer. This paper reviews the efficacy of CAR-T therapy in the treatment of various ... -
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews-Editorial
( American Society for Pharmacology and Experimental Therapy (ASPET) , 2024 , Article)Like many scientists, my first experience with Pharmacological Reviews began when I was a senior undergraduate student. An extensive review in such a highly reputable journal is a gold mine for a student working on a term ... -
Epidemiology and management of gestational diabetes
( Elsevier , 2024 , Article Review)Gestational diabetes is defined as hyperglycaemia first detected during pregnancy at glucose concentrations that are less than those of overt diabetes. Around 14% of pregnancies globally are affected by gestational diabetes; ... -
Prevalence and factors associated with falls in older adults in a Middle Eastern population: a retrospective cross-sectional study
( Elsevier , 2024 , Article)Objective The main objective was to determine the prevalence of falls and associated factors in older adults living in Qatar. Study design Cross-sectional study. Methods This is a cross-sectional study of older ... -
New Generation Anti-Obesity Pharmacotherapy: Companion or Competitor to Metabolic bariatric Surgery?
( Elsevier , 2024 , Article)Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which were originally developed and approved for the management of type 2 diabetes, have recently been demonstrated to yield significant weight loss accompanied by ... -
Erratum: Prevalence and determinants of symptomatic COVID-19 infection among children and adolescents in Qatar: A cross-sectional analysis of 11 445 individuals (Epidemiology and Infection (2021) 149 (E193) DOI: 10.1017/S0950268821001515)
( Cambridge University Press , 2021 , Article)The original version of this article was published with a mistake in one of the authors’ names. “Abdallah Musa Abdallah” is the correct full name but this was initially published as just “Abdallah Musa”. This has now been ... -
Prevalence and determinants of symptomatic COVID-19 infection among children and adolescents in Qatar: a cross-sectional analysis of 11 445 individuals
( NLM (Medline) , 2021 , Article)[No abstract available] -
Metabolic predictors of COVID-19 mortality and severity: a survival analysis
( Frontiers Media SA , 2024 , Article)Introduction: The global healthcare burden of COVID-19 pandemic has been unprecedented with a high mortality. Metabolomics, a powerful technique, has been increasingly utilized to study the host response to infections and ... -
Neuronal diversity in the caudate nucleus: A comparative study between camel and human brains.
( Wiley , 2024 , Article)Caudate nucleus (CN) neurons in camels and humans were examined using modified Golgi impregnation methods. Neurons were classified based on soma morphology, dendritic characteristics, and spine distribution. Three primary ...
