College of Medicine: Recent submissions
Now showing items 261-280 of 1543
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Thromboxane biosynthesis and future events in diabetes: the ASCEND trial
( Oxford University Press , 2024 , Article)Background and Thromboxane (TX) A2, released by activated platelets, plays an important role in atherothrombosis. Urinary 11-dehydro-Aims TXB2 (U-TXM), a stable metabolite reflecting the whole-body TXA2 biosynthesis, is ... -
Is medical training solely to blame? Generational influences on the mental health of our medical trainees
( Taylor & Francis , 2024 , Article)Introduction: The negative impact of medical training on trainee mental health continues to be a concern. Situated within a sociocultural milieu, Generation Z and Generation Y, defined by their highly involved parents and ... -
From tackles to trauma: investigating the influence of the FIFA World Cup 2022 on public maxillofacial department in Qatar - an observational study.
( Wolters Kluwer Health , 2024 , Article)The Federation Internationale de Football Association (FIFA) World Cup (FIFA-WC) is considered the pinnacle of international sporting events, attracting a diverse array of attendees from across the globe1. Hosting such an ... -
A Pilot Randomized Controlled Trial of De Novo Belatacept-based Immunosuppression After Lung Transplantation.
( Wolters Kluwer Health , 2024 , Article)Chronic lung allograft dysfunction (CLAD) is the leading cause of death beyond the first year after lung transplantation. The development of donor-specific antibodies (DSA) is a recognized risk factor for CLAD. Based on ... -
Determining the conclusiveness of a meta-analysis.
( Wolters Kluwer Health , 2024 , Article)The pursuit of conclusive evidence related to an unanswered foreground (decision-making) question has been the driving factor behind multiple ongoing and planned randomized controlled trials as well as meta-analyses. ... -
Comparison of bias adjustment in meta-analysis using data-based and opinion-based methods.
( Wolters Kluwer Health , 2024 , Article)Several methods exist for bias adjustment of meta-analysis results, but there has been no comprehensive comparison with unadjusted methods. We compare 6 bias-adjustment methods with 2 unadjusted methods to examine how these ... -
Excision and Reconstruction of Atypical Chest Dermatofibrosarcoma Protuberans Tumor: A Case Report and Literature Review.
( Karger , 2024 , Article)Dermatofibrosarcoma protuberans (DFSP) originated as keloid sarcoma, gaining its current designation in 1925. DFSP exhibits slow growth, categorizing it as a low- to intermediate-grade malignant sarcoma. Initially presenting ... -
Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials.
( Springer Nature , 2024 , Article)Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recognized. We aimed ... -
Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways.
( Springer Nature , 2024 , Article)Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast ... -
Correction: Statistical analysis plan and protocol updates for Gestational diabetes in Uganda and India: Design and Evaluation of Educational Films for Improving Screening and Self-management (GUIDES) trial.
( BioMed Central (BMC) , 2024 , Article)Following publication of the original article [1], we have been notified that the 5th author’s affiliation was incorrect. Corrected affiliation: Giridhara R Babu, Professor of Global Health, Department of Population ... -
Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis
( Elsevier , 2024 , Article Review)BackgroundThe placenta acts as a buffer to regulate the degree of fetal exposure to maternal cortisol through the 11-Beta Hydroxysteroid Dehydrogenase isoenzyme type 2 (11-β HSD2) enzyme. We conducted a systematic review ... -
A combined strategies intervention on the World Health Organization prescribing indicators: A quasi-randomised trial.
( AOSIS Publishing , 2024 , Article)Irrational medicine use is a global problem that may potentiate antimicrobial resistance. This study aims to assess prescribing practices and the effect of a prescription audit and feedback coupled with small-group education ... -
Comparison of postoperative pain in children after maintenance anaesthesia with propofol or sevoflurane: a systematic review and meta-analysis.
( Elsevier , 2024 , Article Review)Propofol and sevoflurane are two of the most commonly used anaesthetics for paediatric surgery. Data from some clinical trials suggest that postoperative pain incidence is lower when propofol is used for maintenance of ... -
CCN3, POSTN, and PTHLH as potential key regulators of genomic integrity and cellular survival in iPSCs
( Frontiers Media SA , 2024 , Article)Reprogramming human somatic cells into a pluripotent state, achieved through the activation of well-defined transcriptional factors known as OSKM factors, offers significant potential for regenerative medicine. While OSKM ... -
Metabolomic profiling reveals key metabolites associated with hypertension progression
( Frontiers Media SA , 2024 , Article)Introduction: Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for ... -
Incidence, clinical features, and outcomes of posterior circulation ischemic stroke: insights from a large multiethnic stroke database
( Frontiers Media SA , 2024 , Article)Background: Posterior cerebral circulation ischemic stroke (PCS) comprises up to 25% of all strokes. It is characterized by variable presentation, leading to misdiagnosis and morbidity and mortality. We aim to describe PCS ... -
What Matters Most: Determinants Associated with the Selection of Medical Residencies in Qatar
( Dove Medical Press Ltd , 2024 , Article)Purpose: There have been several studies into medical student career decision making in occidental countries (eg US, UK), but medical career selection in a Middle Eastern context has not been as well studied. This study ... -
Estimates of the prevalence of male circumcision in sub-Saharan Africa from 2010-2023 -A systematic review and meta-analysis
( Public Library of Science , 2024 , Article)Background Male circumcision (MC) is a key part of the package of interventions to prevent HIV, the biggest health challenge in sub-Saharan Africa. Objective To estimate the male circumcision prevalence and to evaluate the ... -
Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis
( BioMed Central Ltd , 2024 , Article Review)Background Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims ... -
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
( Medicinska Naklada Zagreb , 2024 , Article)Uterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavo-rable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, ...
