Comparing the metabolic signatures of obesity defined by waist circumference, waist-hip ratio, or BMI
Date
2024Metadata
Show full item recordAbstract
Objective: Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist-hip ratio. This study aimed to determine the metabolic signatures associated with each measure of obesity in the Qatari population. Methods: Metabolomics profiling was conducted to identify, quantify, and characterize metabolites in serum samples from the study participants. Inverse rank normalization, principal component analysis, and orthogonal partial least square-discriminant analysis were used to analyze the metabolomics data. Results: This study revealed significant differences in metabolites associated with obesity based on different measurements. In men, phosphatidylcholine and phosphatidylethanolamine metabolites were significantly enriched in individuals classified as having obesity based on the waist-hip ratio. In women, significant changes were observed in leucine, isoleucine, and valine metabolism metabolites. Unique metabolites were found in the different categorization groups that could serve as biomarkers for assessing many obesity-related disorders. Conclusions: This study identified unique metabolic signatures associated with obesity based on different measurements in the Qatari population. These findings contribute to a better understanding of the molecular pathways involved in obesity and may have implications for developing personalized prevention and treatment strategies.
Collections
- Biomedical Research Center Research [736 items ]
- Biomedical Sciences [720 items ]
- Medicine Research [1457 items ]
Related items
Showing items related by title, author, creator and subject.
-
The effect of aging on the bone healing properties of blood plasma
Al-Hamed F.S.; Rodan R.; Ramirez-Garcialuna J.L.; Elkashty O.; Al-Shahrani N.; Tran S.D.; Lordkipanidz� M.; Kaartinen M.; Badran Z.; Tamimi F.... more authors ... less authors ( Elsevier Ltd , 2021 , Article)Objectives: Age-related changes in blood composition have been found to affect overall health. Thus, this study aimed to understand the effect of these changes on bone healing by assessing how plasma derived from young and ... -
Statistical methods and resources for biomarker discovery using metabolomics.
Anwardeen, Najeha R; Diboun, Ilhame; Mokrab, Younes; Althani, Asma A; Elrayess, Mohamed A ( BMC , 2023 , Article Review)Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ... -
Statistical methods and resources for biomarker discovery using metabolomics
Anwardeen, Najeha R.; Diboun, Ilhame; Mokrab, Younes; Althani, Asma A.; Elrayess, Mohamed A. ( Springer Nature , 2023 , Article)Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ...