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AuthorHarfouche, Manale
AuthorAlareeki, Asalah
AuthorOsman, Aisha M.M.
AuthorAlaama, Ahmed S.
AuthorHermez, Joumana G.
AuthorAbu-Raddad, Laith J.
Available date2023-05-11T10:38:48Z
Publication Date2023-02-23
Publication NameJournal of Medical Virology
Identifierhttp://dx.doi.org/10.1002/jmv.28603
CitationHarfouche, M., Alareeki, A., Osman, A. M., Alaama, A. S., Hermez, J. G., & Abu‐Raddad, L. J. (2023). Epidemiology of herpes simplex virus type 2 in the Middle East and North Africa: Systematic review, meta‐analyses, and meta‐regressions. Journal of Medical Virology.
ISSN0146-6615
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151167970&origin=inward
URIhttp://hdl.handle.net/10576/42643
AbstractHerpes simplex virus type 2 (HSV-2) infection is a prevalent, sexually transmitted infection with poorly characterized prevalence in the Middle East and North Africa (MENA) region. This study characterized HSV-2 epidemiology in MENA. HSV-2 reports were systematically reviewed as guided by the Cochrane Collaboration Handbook and findings were reported following PRISMA guidelines. Random-effects meta-analyses and meta-regressions were performed to estimate pooled mean outcome measures and to assess predictors of HSV-2 antibody prevalence (seroprevalence), trends in seroprevalence, and between-study heterogeneity. In total, sixty-one overall (133 stratified) HSV-2 seroprevalence measures and two overall (four stratified) proportion measures of HSV-2 detection in laboratory-confirmed genital herpes were extracted from 37 relevant publications. Pooled mean seroprevalence was 5.1% (95% confidence interval [CI]: 3.6%–6.8%) among general populations, 13.3% (95% CI: 8.6%–18.7%) among intermediate-risk populations, 20.6% (95% CI: 5.3%–42.3%) among female sex workers, and 18.3% (95% CI: 3.9%–39.4%) among male sex workers. Compared to Fertile Crescent countries, seroprevalence was 3.39-fold (95% CI: 1.86–6.20) and 3.90-fold (95% CI: 1.78–8.57) higher in Maghreb and Horn of Africa countries, respectively. Compared to studies published before 2010, seroprevalence was 1.73-fold (95% CI: 1.00–2.99) higher in studies published after 2015. Pooled mean proportion of HSV-2 detection in genital herpes was 73.8% (95% CI: 42.2%–95.9%). In conclusion, MENA has a lower HSV-2 seroprevalence than other world regions. Yet, 1 in 20 adults is chronically infected, despite conservative prevailing sexual norms. Seroprevalence may also be increasing, unlike other world regions. Findings support the need for expansion of surveillance and monitoring of HSV-2 infection in MENA.
SponsorThis work was supported by the Qatar National Research Fund [NPRP 9-040-3-008] and by pilot funding from the Biomedical Research Program at Weill Cornell Medicine in Qatar.
Languageen
PublisherWiley-Blackwell
Subjectgenital
genital herpes
genital ulcer disease
Herpes
HSV-2
MENA
prevalence
seroprevalence
sexually transmitted infection
TitleEpidemiology of herpes simplex virus type 2 in the Middle East and North Africa: Systematic review, meta-analyses, and meta-regressions
TypeArticle
Issue Number3
Volume Number95
ESSN1096-9071
dc.accessType Open Access


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