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المؤلفKhan, Muhammad Umar Aslam
المؤلفAl-Arjan, Wafa Shamsan
المؤلفAshammakhi, Nureddin
المؤلفHaider, Sajjad
المؤلفAmin, Rashid
المؤلفHasan, Anwarul
تاريخ الإتاحة2023-06-08T10:30:05Z
تاريخ النشر2022
اسم المنشورACS Applied Bio Materials
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1021/acsabm.2c00777
معرّف المصادر الموحدhttp://hdl.handle.net/10576/44232
الملخصAdvanced biomaterials are required with enhanced antibacterial and anticancer activities to obtain desirable biocompatibility during and after scaffold implantation in tissue engineering. Here, we report the development of a nanosystem by the hydrothermal method using different zinc (Zn) amounts and reduced graphene oxide (GO). Arabinoxylan, the nanosystem (Zn@rGO), and nanohydroxyapatite polymeric nanocomposites ARX-g-(Zn@rGO)/HAp were prepared by the free radical polymerization method, and porous bioactive scaffolds were fabricated via the freeze-drying technique. The structural, morphological, and elemental analyses of the bioactive scaffolds were conducted using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray analysis. The wetting behavior was studied by a water contact meter and swelling in aqueous and phosphate-buffered saline solutions at 37 °C. The degradation was also studied in the phosphate-buffered saline solution at 37 °C. The increase in Zn content increased the pore size, and hydrophobic behavior shifted to hydrophilic (AGZ-1 = 131.40° at 0 s and 120.60° at 10 s to AGZ-1 = 81.30° at 0 s and 69.20° at 10 s) with the increase in contact time. Maximum swelling was observed in deionized water (AGZ-1 = 52.87%, AGZ-4 = 90.20%), followed by phosphate-buffered saline (PBS; AGZ-1 = 44.80%, AGZ-4 = 67.90%) and electrolyte (AGZ-1 = 32.40%, AGZ-4 = 63.47%), and biodegradation in PBS media increased (AGZ-1 = 36.80%, AGZ-4 = 55.92%). Antimicrobial activities against severe infection-causing pathogens and antitumor activity against U87 cell lines showed exceptional results. Cell viability and cell proliferation studies were conducted against preosteoblast cell lines, and increased cell viability and proliferation were observed from AGZ-1 to AGZ-4. Antimicrobial and anticancer activities were enhanced with the increase of Zn content in the Zn@rGO system. The bioactive scaffolds with different formulations could be potential biomaterials to treat and regenerate defected bone tissue.
راعي المشروعThis research was made possible through the Qatar National Research Foundation Grant NPRP12S-0310-190276. All statements made herein are the sole responsibility of the authors.
اللغةen
الناشرAmerican Chemical Society
الموضوعantibacterial
anticancer
biocompatible
nanotechnology
tissue engineering
العنوانMultifunctional Bioactive Scaffolds from ARX- g-(Zn@rGO)-HAp for Bone Tissue Engineering: In Vitro Antibacterial, Antitumor, and Biocompatibility Evaluations
النوعArticle
الصفحات5445-5456
رقم العدد11
رقم المجلد5
dc.accessType Abstract Only


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