Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer
Date
2023-04-07Author
Alizadeh, JavadKavoosi, Mahboubeh
Singh, Navjit
Lorzadeh, Shahrokh
Ravandi, Amir
Kidane, Biniam
Ahmed, Naseer
Mraiche, Fatima
Mowat, Michael R.
Ghavami, Saeid
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Show full item recordAbstract
Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.
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