Browsing Biomedical Research Center Research by Author "Marei, Isra"
Now showing items 1-3 of 3
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Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors
Ahmetaj-Shala, Blerina; Marei, Isra; Kawai, Ryota; Rothery, Stephen; Pericleous, Charis; Mohamed, Nura A.; Gashaw, Hime; Bokea, Kalliopi; Samuel, Jake; Vandenheste, Annabelle; Shala, Fisnik; Kirkby, Nicholas S.; Mitchell, Jane A.... more authors ... less authors ( Frontiers Media , 2021 , Article)Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine. However, ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Zekri, Atef; Kameno, Yu; Davies, Robert P.; Lickiss, Paul D.; Rahman, Md Mizanur; Abou-Saleh, Haissam... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
Studies on metal–organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension
Mohamed, Nura A.; Abou-Saleh, Haissam; Kameno, Yu; Marei, Isra; de Nucci, Gilberto; Ahmetaj-Shala, Blerina; Shala, Fisnik; Kirkby, Nicholas S.; Jennings, Lewis; Al-Ansari, Dana E.; Davies, Robert P.; Lickiss, Paul D.; Mitchell, Jane A.... more authors ... less authors ( nature , 2021 , Article)Pulmonary arterial hypertension (PAH) is an incurable disease, although symptoms are treated with a range of dilator drugs. Despite their clinical benefits, these drugs are limited by systemic side-effects. It is, therefore, ...