Biomedical Research Center Research: Recent submissions
Now showing items 1-20 of 875
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Dexamethasone chronotherapy of COVID-19 patients admitted to intensive care unit: an exploratory study
( BioMed Central Ltd , 2025 , Article)Background: Dexamethasone has been demonstrated to be a potential treatment approach preventing COVID-19 related fatalities by managing the cytokine release storm (CRS). The expression of the inflammatory mediators involved ... -
Health-related quality of life of adults with generalized pustular psoriasis in Malaysia: a cross-sectional study
( BioMed Central Ltd , 2025 , Article)Background: Generalized Pustular Psoriasis (GPP) is a rare but severe form of psoriasis, characterized by flares involving the sudden spread of erythema with sterile pustules, crusting, and scaling. Objective: The study ... -
The role of immune checkpoints in modulating cancer stem cells anti-tumor immune responses: implications and perspectives in cancer therapy
( BioMed Central Ltd , 2025 , Article Review)Cancer stem cells (CSCs) are a minor subpopulation of tumor cells characterized by self-renewal capacity and stemness features and are responsible for tumor progression and therapy resistance. Several studies have shown ... -
One Health Antimicrobial Resistance in Qatar: A Comprehensive Systematic Review and Meta-Analysis of Animal, Food, and Environmental Reservoirs
( MDPI , 2025 , Article)Background: Antimicrobial resistance (AMR) is a global threat that extends beyond clinical settings, impacting animals, food, and the environment. To the best of our knowledge, this review presents the first systematic ... -
N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis
( Oxford University Press , 2025 , Article)N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three ... -
Economic burden and cost drivers of generalized pustular psoriasis: a systematic review
( Springer Nature , 2025 , Article)Generalized pustular psoriasis (GPP), as a rare type of life-threatening psoriasis with currently no effective treatment, imposes a huge economic burden on the healthcare systems. This systematic review aimed to summarize ... -
In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)The skin acts as a primary barrier against environmental insults and maintains homeostasis. Injury initiates a wound healing cascade of hemostasis, inflammation, proliferation, and remodeling. In chronic wounds, persistent ... -
Economic burden and cost drivers of interstitial lung disease: a systematic review
( Springer Science and Business Media Deutschland GmbH , 2025 , Article)Background: Interstitial lung disease (ILD) consists of many subtypes, with idiopathic pulmonary fibrosis (IPF) and subtypes that manifest as progressive pulmonary fibrosis (PPF) exhibit faster progression and poorer ... -
Mental health of university students: a cross-sectional study from Qatar
( Nature Research , 2025 , Article)This study explored the prevalence, associated factors, and management strategies related to mental health among university students in Qatar. A cross-sectional survey was conducted among students aged 18 and older. Data ... -
Effectiveness and durability of a fourth dose of ancestral-strain mRNA vaccines against SARS-CoV-2 infection: a nationwide matched cohort study in Qatar
( Nature Research , 2025 , Article)Concerns about waning immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the emergence of new variants underscore the need for booster doses. Using a matched cohort design, this ... -
Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues
( Nature Research , 2025 , Article Review)Essential transcription and cell cycle progression controllers are CDKs, whose dysregulation is a defining trait of many human cancers. CDKs have grown to be very crucial therapeutic targets in cancer. Although traditional ... -
Meta-adaptive biomaterials: multiscale, spatiotemporal organization and actuation in engineered tissues
( Elsevier , 2025 , Article)Organized cell architecture and dynamic forces are key for (re)creating native-like tissue function (e.g., contractile soft tissues). However, few studies have explored the combined effects of material-guided 3D cell ... -
Serogroup W invasive meningococcal disease outbreak in Qatar following travel to Umrah
( Elsevier , 2025 , Article)Invasive meningococcal disease (IMD) is associated with significant morbidity and mortality in all age groups. Globally, reported cases predominantly belong to serogroups A, B, and C. Although serogroup W is less prevalent ... -
Significance, clinical spectrum, and microbiological evaluation of Actinomyces blood stream infections
( Elsevier , 2025 , Article)ObjectivesActinomyces species are Gram-positive anaerobic bacilli that are commensal in the gastrointestinal and genital tracts. Actinomyces blood stream infections (BSIs) are rare but becoming more frequent with advanced ... -
Estimating SARS-CoV-2 infection incidence and detection rates: Demonstrating a novel surveillance method
( Elsevier , 2025 , Article)ObjectivesAssessing the cumulative incidence of infection conventionally relies on documented infections or serological surveys, both of which have limitations. This study introduces a novel and practical method leveraging ... -
Two-dimensional nanomaterials for infection control: A comprehensive review
( Elsevier , 2026 , Article Review)Two-dimensional (2D) nanosheets provide orthogonal, multi-modal strategies to control infection at a time of rising antimicrobial resistance. This review highlights material families most relevant to graphene derivatives, ... -
ANTI-CANCEROUS POTENTIAL OF EXTRACTS OF QATARI PLANTS AGAINST A549 LUNG CANCER CELLS AND IDENTIFICATION OF THEIR BIOACTIVE COMPOUNDS UREP30-002-3-002 (BH - 250026)
( QRDI Council , 2025 , Conference)• Lung cancer is the leading cause of cancer deaths worldwide, with NSCLC accounting for most cases. • In Qatar, incidence is rising, driven by tobacco use and late-stage diagnosis. • Current therapies face major limitations, ... -
Thymol's Nanoencapsulation Reduces its Toxicity in Human Cells and Zebrafish Embryos
( Saudi Pharmacy Association (SPS)- Ministry of Health , 2025 , Conference)Thymol, a monoterpenoid and a major bioactive constituent of essential oils (EOs) derived from the plants of Lamiacea family such as Thyme, garnered wider research interest for its diverse biological activity and industrial ... -
PBA 23: Nanoencapsulation of Thymol Mitigates its Toxicity in Cells and Zebrafish Embryos
( College of Education, Qatar University , 2025 , Conference)Thymol, a monoterpenoid and a major boactive constituent of essential oils (EOs) derived from the plants of Lamiacea species such as Thyme, has garnered wider research interest for its diverse pharmaceutical, food, and ... -
Human primary mesenchymal stem cells fail to recover full osteogenic differentiation potential following washout of electronic cigarette aerosol extracts.
( Oxford University Press , 2025 , Article)Electronic cigarettes (e-cigarettes) are promoted as safer alternatives to combustible cigarettes. However, the health burden and effects of their long-term use remain unidentified. This study evaluates the extent and ...
