Biomedical Research Center Research: المرسلات الحديثة
السجلات المعروضة 21 -- 40 من 736
-
Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications
( MDPI , 2024 , Article Review)The aim of this study is to provide an overview of the current state-of-the-art in the fabrication of bioceramic scaffolds for bone tissue engineering, with an emphasis on the use of three-dimensional (3D) technologies ... -
Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity
( Springer Nature , 2024 , Article)Background: Doxorubicin (DOX) is a potent chemotherapy widely used in treating various neoplastic diseases. However, the clinical use of DOX is limited due to its potential toxic effect on the cardiovascular system. Thus, ... -
Imatinib‑ and ponatinib‑mediated cardiotoxicity in zebrafish embryos and H9c2 cardiomyoblasts
( Spandidos Publications , 2024 , Article)Tyrosine kinase inhibitors (TKIs) offer targeted therapy for cancers but can cause severe cardiotoxicities. Determining their dose‑dependent impact on cardiac function is required to optimize therapy and minimize adverse ... -
Proteomic Analysis of Prehypertensive and Hypertensive Patients: Exploring the Role of the Actin Cytoskeleton
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Hypertension is a pervasive and widespread health condition that poses a significant risk factor for cardiovascular disease, which includes conditions such as heart attack, stroke, and heart failure. Despite its widespread ... -
Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Obesity, characterized by excessive body fat, is closely linked to endoplasmic reticulum (ER) stress, leading to insulin resistance and type 2 diabetes. Inflammatory pathways like c-Jun N-terminal kinase (JNK) worsen insulin ... -
Metabolomics Profiling of Stages of Coronary Artery Disease Progression
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are ... -
QPGx-CARES: Qatar pharmacogenetics clinical applications and research enhancement strategies
( John Wiley and Sons Inc , 2024 , Article Review)Pharmacogenetic (PGx)-informed medication prescription is a cutting-edge genomic application in contemporary medicine, offering the potential to overcome the conventional "trial-and-error" approach in drug prescription. ... -
Material modeling and recent findings in transcatheter aortic valve implantation simulations
( Elsevier , 2024 , Article Review)Background and objective: Transcatheter aortic valve implantation (TAVI) has significantly transformed the management of aortic valve (AV) diseases, presenting a minimally invasive option compared to traditional surgical ... -
Genomic characterization of plasmid-borne colistin resistance variants, mcr-1.1 and mcr-1.26, in multidrug-resistant Escherichia coli isolated from backyard farm animals
( Elsevier , 2024 , Other)Colistin remains a high-priority, critically important antimicrobial that is used for treating severe infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, colistin resistance and the emergence ... -
Epidemiological, molecular, and clinical features of norovirus infections among pediatric patients in Qatar
( MDPI AG , 2019 , Article)Background: Norovirus (NoV) is recognized as the second most important etiological agent leading to acute gastroenteritis globally. In order to determine the burden and characteristics of NoV infections in children in ... -
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children
( Nature Publishing Group , 2019 , Article)Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Infection can be caused ... -
Chitin-based nanomaterials
( Elsevier , 2021 , Book chapter)Chitin- and chitosan-based materials have been increasingly used in various scientific advancements specifically in the field of nanotechnology for their therapeutic potential. They are biopolymeric polysaccharides with ... -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( HBKU Press , 2021 , Article)Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The ... -
Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar's experience
( Edinburgh University Global Health Society , 2022 , Article)Background The effective reproduction number, Rt, is a tool to track and understand pandemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset of ... -
Smoking induced salivary microbiome dysbiosis and is correlated with lipid biomarkers
( Springer Nature , 2024 , Article)Background: The oral microbiome plays an essential role in maintaining oral homeostasis and health; smoking significantly affects it, leading to microbial dysbiosis. The study aims to investigate changes in the oral ... -
The tale of an endemic shrimp’s exceptional osmoregulation and the ancient Athalassic mangrove oasis
( Springer Nature , 2024 , Article)The hyperarid mangrove in the Middle East is characterised by the absence of rivers or freshwater inputs and is one of the most extreme settings of this ecosystem on Earth. Endemic to Qatar’s hyperarid mangroves, a Palaemon ... -
Role of genetics in eleven of the most common autoimmune diseases in the post genome-wide association studies era
( Verduci Editore s.r.l , 2023 , Article)Autoimmune diseases (ADs) are common conditions in which an individual’s immune system reacts against its healthy cells. This condition is a common cause of morbidity and mortality, with an estimated prevalence ranging ... -
Rapid Visual Detection of Methicillin-Resistant Staphylococcus aureus in Human Clinical Samples via Closed LAMP Assay Targeting mecA and spa Genes
( MDPI , 2024 , Article)The emergence of antimicrobial resistance (AMR), particularly methicillin-resistant Staphylococcus aureus (MRSA), poses a significant global health threat as these bacteria increasingly become resistant to the most available ... -
Antimicrobial Resistance in Qatar: Prevalence and Trends before and Amidst the COVID-19 Pandemic
( MDPI , 2024 , Article)Antimicrobial resistance (AMR) is a global healthcare challenge with substantial morbidity, mortality, and management costs. During the COVID-19 pandemic, there was a documented increase in antimicrobial consumption, ... -
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
( Springer Nature , 2024 , Article)Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ...