Biomedical Research Center Research: Recent submissions
Now showing items 301-320 of 840
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Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar
( Springer Nature , 2023 , Article)Background: We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines. Methods: Rotavirus-positive samples (n = 231) were collected and ... -
Protection against Reinfection with the Omicron BA.2.75 Subvariant
( Massachusetts Medical Society , 2023 , Other)The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) ... -
Qatar genome: Insights on genomics from the Middle East
( Wiley , 2022 , Article)Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we ... -
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches
( Springer , 2021 , Article Review)We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ... -
Epac as a tractable therapeutic target
( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon
( Wiley , 2020 , Article)Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ... -
Nanomedicine as a Potential Tool against Monkeypox.
( MDPI , 2023 , Article Review)Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ... -
Traumatic Brain Injury Can Affect Emotions and Behaviors
( Frontiers Media , 2023 , Article)Proper brain functioning is responsible for our feelings, behavior, and thinking. However, an injury to the brain can disrupt brain function, which can affect our emotions and behaviors. A traumatic brain injury (TBI) can ... -
The power of phytochemicals combination in cancer chemoprevention
( Ivyspring International Publisher , 2020 , Article Review)Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ... -
Nox2 activity is required in obesity-mediated alteration of bone remodeling
( Hindawi Limited , 2018 , Article)Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the ... -
Intercellular Communication in Cancer
( Springer , 2023 , Book chapter)Junctional complexes play a central role in maintaining tissue hemostasis. The barrier function of epithelial cells, that maintain tissues coherence and coordination of cellular synchronicity, is a consequence of a junctional ... -
Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines.
( MDPI , 2023 , Article)Gap-junction-forming connexins are exquisitely regulated by post-translational modifications (PTMs). In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. Here, we ... -
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
( Elsevier Ltd , 2022 , Article Review)Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ... -
How does hemodynamics affect rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters, time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative residence time
( Elsevier , 2023 , Article)An abdominal aortic aneurysm (AAA) is a critical health condition with a risk of rupture, where the diameter of the aorta enlarges more than 50% of its normal diameter. The incidence rate of AAA has increased worldwide. ... -
Nanomedicine for Cancer.
( Bentham Science Publishers , 2022 , Article)Over the past decades, oncology has occupied the lion’s share of all nanomedical applications [1-3]. In 2020, up to 65% of the clinical trials involving nanomaterials were attending to cancer therapeutics and diagnostics ... -
A comprehensive review on the antiviral activities of chalcones
( Taylor and Francis Ltd. , 2021 , Article)Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ... -
Association between waterpipe smoking and obesity: Population-based study in Qatar
( European Publishing , 2022 , Article)Introduction: Over the past decade obesity prevalence has been increasing rapidly in the Gulf region (GR) including Qatar, becoming one of the major health issues in the region. Concomitantly, waterpipe (WP) smoking is ... -
Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
( Elsevier Masson s.r.l. , 2020 , Article)Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ... -
Snornas and mirnas networks underlying covid-19 disease severity
( MDPI , 2021 , Article)There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ...
