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AuthorMezentsev, Alexandre
AuthorBezsonov, Evgeny
AuthorKashirskikh, Dmitry
AuthorBaig, Mirza S.
AuthorEid, Ali H.
AuthorOrekhov, Alexander
Available date2023-07-31T11:37:21Z
Publication Date2021-05-25
Publication NameBiomedicines
Identifierhttp://dx.doi.org/10.3390/biomedicines9060600
CitationMezentsev, A., Bezsonov, E., Kashirskikh, D., Baig, M. S., Eid, A. H., & Orekhov, A. (2021). Proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside. Biomedicines, 9(6), 600.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85107801073&origin=inward
URIhttp://hdl.handle.net/10576/46443
AbstractThis review summarizes the main achievements in basic and clinical research of atheroscle-rosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoproteins and decreases the anti-atherogenic properties of high density lipoproteins. The separate sections of this paper are devoted to immunogenicity of lipoproteins, the enzymes contribut-ing to their desialylation and animal models of atherosclerosis. In addition, we evaluate the available experimental and diagnostic protocols that can be used to develop new therapeutic approaches for atherosclerosis.
SponsorThis research was funded by the Russian Science Foundation, grant number 18-15-00254.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
SubjectAnimal models of atherosclerosis
Anti-LDL antibodies
Apolipoproteins
Atherogenesis
Desialylation
Diagnostics of atherosclerosis
HDL
LDL
Sialidase
Trans-sialidase
Treatment options for atherosclerosis
TitleProatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside
TypeArticle
Issue Number6
Volume Number9
ESSN2227-9059
dc.accessType Open Access


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