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المؤلفMamun, Abdullah
المؤلفBiswas, Tuhin
المؤلفScott, James
المؤلفSly, Peter D.
المؤلفMcIntyre, H. David
المؤلفThorpe, Karen
المؤلفBoyle, Frances M.
المؤلفDekker, Marloes N.
المؤلفDoi, Suhail
المؤلفMitchell, Murray
المؤلفMcNeil, Keith
المؤلفKothari, Alka
المؤلفHardiman, Leah
المؤلفCallaway, Leonie Kaye
تاريخ الإتاحة2023-09-10T09:01:11Z
تاريخ النشر2023-08-03
اسم المنشورBMJ Open
المعرّفhttp://dx.doi.org/10.1136/bmjopen-2022-063826
الاقتباسMamun A, Biswas T, Scott J, et alAdverse childhood experiences, the risk of pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysisBMJ Open 2023;13:e063826. doi: 10.1136/bmjopen-2022-063826
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166579099&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47346
الملخصBackground Adverse childhood experiences (ACEs) have a profound negative impact on health. However, the strength of the association between ACEs and pregnancy complications and adverse pregnancy outcomes is not well quantified or understood. Objective To conduct a systematic review and meta-analysis of the association between ACEs and risk of pregnancy complications and adverse pregnancy outcomes. Search strategy A comprehensive search was conducted using PubMed, Embase, CINAHL, PsycINFO, ClinicalTrials.gov and Google scholar up to July 2022. Data collection and analysis Two reviewers independently conducted the screening and quality appraisal using a validated tool. Meta-analysis using the quality-effects model on the reported odds ratio (OR) was conducted. Heterogeneity and inconsistency were examined using the I 2 statistics. Results 32 studies from 1508 met a priori inclusion criteria for systematic review, with 21 included in the meta-analysis. Pooled analyses showed that exposure to ACEs increased the risk of pregnancy complications (OR 1.37, 95% CI 1.20 to 1.57) and adverse pregnancy outcomes (OR 1.31, 95% CI 1.17 to 1.47). In sub-group analysis, maternal ACEs were associated with gestational diabetes mellitus (OR 1.39, 95% CI 1.11 to 1.74), antenatal depression (OR 1.59, 95% CI 1.15 to 2.20), low offspring birth weight (OR 1.27, 95% CI 1.02 to 1.47), and preterm delivery (OR 1.41, 95% CI 1.16 to 1.71). Conclusion The results suggest that exposure to ACEs increases the risk of pregnancy complications and adverse pregnancy outcomes. Preventive strategies, screening and trauma-informed care need to be examined to improve maternal and child health.
راعي المشروعThis research was partially supported by the Australian Research Council Centre of Excellence for Children and Families over the Life Course (CE200100025).
اللغةen
الناشرBMJ Publishing Group
الموضوعadverse events
diabetes in pregnancy
epidemiology
epidemiology
prenatal diagnosis
العنوانAdverse childhood experiences, the risk of pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis
النوعArticle
رقم العدد8
رقم المجلد13
ESSN2044-6055
dc.accessType Open Access


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