Identification of cortactin molecular forms in human urine and their possible diagnostic value
| المؤلف | Starykovych, M. |
| المؤلف | Souchelnytskyi, S. |
| المؤلف | Fayura, O. |
| المؤلف | Abrahamovych, O. |
| المؤلف | Abrahamovych, M. |
| المؤلف | Lukavetskyy, N. |
| المؤلف | Stoika, R. |
| المؤلف | Kit, Y. |
| تاريخ الإتاحة | 2023-09-18T10:37:08Z |
| تاريخ النشر | 2021-07-01 |
| اسم المنشور | Ukrainian Biochemical Journal |
| المعرّف | http://dx.doi.org/10.15407/ubj93.04.103 |
| الاقتباس | Starykovych, M., Stoika, R., Kit, Y., Souchelnytskyi, S., Fayura, O., Abrahamovych, O., ... & Lukavetskyy, N. (2021). Identification of cortactin molecular forms in human urine and their possible diagnostic value. The Ukrainian Biochemical Journal, 93(4), 103-110. |
| الرقم المعياري الدولي للكتاب | 24094943 |
| الملخص | The protein composition of human urine reflects changes in the biochemical and physiological status of an individual and has an essential diagnostic value. Using precipitation/extraction methods we isolated a protein with Mr ~100 kDa in a human urine. MALDI TOF/TOF mass spectrometry identified this protein as human Src protein kinase substrate cortactin (UniProtKB/Swiss-Prot: Q14247). Screening of urine samples using Western blotting with specific anti-human cortactin antibodies revealed different proteins immunologi-cally related to cortactin in healthy humans and patients with liver cirrhosis and lung cancer diseases. These data suggest that the level of cortacins isoform in urine might serve as a potential marker for testing acute and systemic diseases. |
| اللغة | en |
| الناشر | Palladin Institute of Biochemistry of the NASU |
| الموضوع | Cortactins Human urine Liver cirrhosis Lung cancer |
| النوع | Article |
| الصفحات | 103-110 |
| رقم العدد | 4 |
| رقم المجلد | 93 |
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