Identification of cortactin molecular forms in human urine and their possible diagnostic value
| Author | Starykovych, M. |
| Author | Souchelnytskyi, S. |
| Author | Fayura, O. |
| Author | Abrahamovych, O. |
| Author | Abrahamovych, M. |
| Author | Lukavetskyy, N. |
| Author | Stoika, R. |
| Author | Kit, Y. |
| Available date | 2023-09-18T10:37:08Z |
| Publication Date | 2021-07-01 |
| Publication Name | Ukrainian Biochemical Journal |
| Identifier | http://dx.doi.org/10.15407/ubj93.04.103 |
| Citation | Starykovych, M., Stoika, R., Kit, Y., Souchelnytskyi, S., Fayura, O., Abrahamovych, O., ... & Lukavetskyy, N. (2021). Identification of cortactin molecular forms in human urine and their possible diagnostic value. The Ukrainian Biochemical Journal, 93(4), 103-110. |
| ISSN | 24094943 |
| Abstract | The protein composition of human urine reflects changes in the biochemical and physiological status of an individual and has an essential diagnostic value. Using precipitation/extraction methods we isolated a protein with Mr ~100 kDa in a human urine. MALDI TOF/TOF mass spectrometry identified this protein as human Src protein kinase substrate cortactin (UniProtKB/Swiss-Prot: Q14247). Screening of urine samples using Western blotting with specific anti-human cortactin antibodies revealed different proteins immunologi-cally related to cortactin in healthy humans and patients with liver cirrhosis and lung cancer diseases. These data suggest that the level of cortacins isoform in urine might serve as a potential marker for testing acute and systemic diseases. |
| Language | en |
| Publisher | Palladin Institute of Biochemistry of the NASU |
| Subject | Cortactins Human urine Liver cirrhosis Lung cancer |
| Type | Article |
| Pagination | 103-110 |
| Issue Number | 4 |
| Volume Number | 93 |
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