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المؤلفBangaBangash M.A.
المؤلفAlles, Sascha R. A.
المؤلفSantana-Varela, Sonia
المؤلفMillet, Queensta
المؤلفSikandar, Shafaq
المؤلفde Clauser, Larissa
المؤلفTer Heegde, Freija
المؤلفHabib, Abdella M.
المؤلفPereira, Vanessa
المؤلفSexton, Jane E.
المؤلفEmery, Edward C.
المؤلفLi, Shengnan
المؤلفLuiz, Ana P.
المؤلفErdos, Janka
المؤلفGossage, Samuel J.
المؤلفZhao, Jing
المؤلفCox, James J.
المؤلفWood, John N.
تاريخ الإتاحة2023-09-20T08:47:12Z
تاريخ النشر2018
اسم المنشورWellcome Open Research
المصدرScopus
الرقم المعياري الدولي للكتاب2398502X
معرّف المصادر الموحدhttp://dx.doi.org/10.12688/wellcomeopenres.14641.1
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47808
الملخصBackground: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression using microarrays in mouse models related to human chronic pain. Methods: Six different pain models were studied in male C57BL/6J mice: (1) bone cancer pain using cancer cell injection in the intramedullary space of the femur; (2) neuropathic pain using partial sciatic nerve ligation; (3) osteoarthritis pain using mechanical joint loading; (4) chemotherapy-induced pain with oxaliplatin; (5) chronic muscle pain using hyperalgesic priming; and (6) inflammatory pain using intraplantar complete Freund's adjuvant. Microarray analyses were performed using RNA isolated from dorsal root ganglia and compared to sham/vehicle treated controls. Results: Differentially expressed genes (DEGs) were identified. Known and previously unreported genes were found to be dysregulated in each pain model. The transcriptomic profiles for each model were compared and expression profiles of DEGs within subsets of DRG neuronal populations were analysed to determine whether specific neuronal subsets could be linked to each of the pain models. Conclusions: Each pain model exhibits a unique set of altered transcripts implying distinct cellular responses to different painful stimuli. No simple direct link between genetically distinct sets of neurons and particular pain models could be discerned.
اللغةen
الناشرF1000 Research Ltd
الموضوعChronic pain
Dorsal root ganglia
Gene expression
Microarrays
Mouse models
Sensory neurons
العنوانDistinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved]
النوعArticle
رقم المجلد3
dc.accessType Open Access


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