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AuthorBangaBangash M.A.
AuthorAlles, Sascha R. A.
AuthorSantana-Varela, Sonia
AuthorMillet, Queensta
AuthorSikandar, Shafaq
Authorde Clauser, Larissa
AuthorTer Heegde, Freija
AuthorHabib, Abdella M.
AuthorPereira, Vanessa
AuthorSexton, Jane E.
AuthorEmery, Edward C.
AuthorLi, Shengnan
AuthorLuiz, Ana P.
AuthorErdos, Janka
AuthorGossage, Samuel J.
AuthorZhao, Jing
AuthorCox, James J.
AuthorWood, John N.
Available date2023-09-20T08:47:12Z
Publication Date2018
Publication NameWellcome Open Research
ResourceScopus
ISSN2398502X
URIhttp://dx.doi.org/10.12688/wellcomeopenres.14641.1
URIhttp://hdl.handle.net/10576/47808
AbstractBackground: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression using microarrays in mouse models related to human chronic pain. Methods: Six different pain models were studied in male C57BL/6J mice: (1) bone cancer pain using cancer cell injection in the intramedullary space of the femur; (2) neuropathic pain using partial sciatic nerve ligation; (3) osteoarthritis pain using mechanical joint loading; (4) chemotherapy-induced pain with oxaliplatin; (5) chronic muscle pain using hyperalgesic priming; and (6) inflammatory pain using intraplantar complete Freund's adjuvant. Microarray analyses were performed using RNA isolated from dorsal root ganglia and compared to sham/vehicle treated controls. Results: Differentially expressed genes (DEGs) were identified. Known and previously unreported genes were found to be dysregulated in each pain model. The transcriptomic profiles for each model were compared and expression profiles of DEGs within subsets of DRG neuronal populations were analysed to determine whether specific neuronal subsets could be linked to each of the pain models. Conclusions: Each pain model exhibits a unique set of altered transcripts implying distinct cellular responses to different painful stimuli. No simple direct link between genetically distinct sets of neurons and particular pain models could be discerned.
Languageen
PublisherF1000 Research Ltd
SubjectChronic pain
Dorsal root ganglia
Gene expression
Microarrays
Mouse models
Sensory neurons
TitleDistinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved]
TypeArticle
Volume Number3


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