Biomedical Sciences: المرسلات الحديثة
السجلات المعروضة 481 -- 500 من 711
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Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion
( Wiley Open Access , 2020 , Article)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the ... -
Cadmium induces migration of colon cancer cells: Roles of reactive oxygen species, p38 and cyclooxygenase-2
( Cell Physiol Biochem Press GmbH & Co KG , 2019 , Article)Background/Aims: Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. Methods: A ... -
Impact of physical exercise on gut microbiome, inflammation, and the pathobiology of metabolic disorders
( Society for Biomedical Diabetes Research , 2019 , Article)BACKGROUND: The gastrointestinal tract (GIT) harbors a complex and diverse microbial composition that outnumbers our own body cells and their gene contents. These microbes play a significant role in host metabolism and ... -
D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis
( Frontiers Media , 2020 , Article Review)Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, ... -
A novel homozygous TPM1 mutation in familial pediatric hypertrophic cardiomyopathy and in silico screening of potential targeting drugs.
( Verduci Editore s.r.l. , 2020 , Article)Familial hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease. While sarcomeric gene mutations explain many HCM cases, the genetic basis of about half of HCM cases remains elusive. Here we aimed to ... -
Effect of flow-induced shear stress in nanomaterial uptake by cells: Focus on targeted anti-cancer therapy
( MDPI , 2020 , Article)© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, ... -
"green" ZnO-Interlinked Chitosan Nanoparticles for the Efficient Inhibition of Sulfate-Reducing Bacteria in Inject Seawater
( American Chemical Society , 2018 , Article)Antimicrobial agents and corrosion inhibitors are widely used as biocides in the oil and gas industry to disinfect water and inhibit excessive biofilm formation caused mainly by sulfate reducing bacteria (SRBs). However, ... -
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
( Wiley Open Access , 2020 , Article)Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ... -
The polymorphism at the microRNA-155 binding site in AGTR1 gene is not significantly associated with rheumatic heart disease in Saudi Arabia population
( Bentham Science Publishers , 2020 , Article)Rheumatic heart disease (RHD) remains a major cause of cardiovascular diseases and the most devastating effects are on children and young adults. RHD is caused due to the interaction between microbial, environmental, ... -
The Expression of TBC1 Domain Family, Member 4 (TBC1D4) in Skeletal Muscles of Insulin-Resistant Mice in Response to Sulforaphane
( Endocrine Society , 2020 , Conference Paper)The Expression of TBC1 Domain Family, member 4 (TBC1D4) in Skeletal Muscles of Insulin-Resistant Mice in Response to Sulforaphane. Background: Obesity is commonly accompanied by impaired glucose homeostasis. Decreased ... -
TLR4 Receptor D299G/T399I Haplotype Polymorphism Is Associated with Insulin Resistance in Obese Female Subjects
(2020 , Article)Background: Activation of Toll-like-receptor 4 (TLR4) causes chronic inflammation that can result in obesity and metabolic syndrome (MeS). Aim: This study aimed to investigate the role of TLR4 polymorphisms of TLR4D299G/T399I, ... -
iTRAQ-based quantitative protein expression profiling and MRM verification of markers in type 2 diabetes.
( American Chemical Society , 2012 , Article)The pathogenesis of Type 2 diabetes mellitus (T2DM) is complex owing to molecular heterogeneity in the afflicted population. Current diagnostic methods rely on blood glucose measurements, which are noninformative with ... -
Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus
( Dove Medical Press , 2020 , Article)© 2020 Cheema et al. Objective: The objective of the current study is to accomplish a relative exploration of the biological roles of differentially dysregulated genes (DRGs) in type 2 diabetes mellitus (T2DM). The study ... -
Enzyme therapy: a forerunner in catalyzing a healthy society?
( Taylor & Francis , 2020 , Article)The use of enzymes in various industries has been prevalent for centuries. However, their potency as therapeutics remained latent until the late 1950 s, when scientists finally realized the gold mine they were sitting on. ... -
CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin
( Ivyspring International Publisher , 2020 , Article)Beyond their role in bone and lung homeostasis, mesenchymal stem cells (MSCs) are becoming popular in cell therapy. Various insults may disrupt the repair mechanisms involving MSCs. One such insult is smoking, which is a ... -
Obesity is associated with depression in Malaysian schoolchildren: A cross-sectional study
( Universitas Indonesia , 2020 , Article)Background: Overweight and obesity, which may lead to depression, have become prevalent among children worldwide. Hence, this study aimed to measure obesity and depression among schoolchildren in Kuantan. Methods: This ... -
New markers for the detection of polycystic ovary syndrome
( MedCrave Group , 2019 , Article)Polycystic Ovary Syndrome (PCOS) is a highly prevalent, complex genetic disorder of the endocrine system in women. Alterations that occur in women with PCOS can be due to several predisposing factors; among these contributors ... -
Association of Urinary Vitamin D-binding Protein and Megalin as Biomarkers for Diabetic Nephropathy in Type 2 Diabetes Mellitus in Qatari Patients
( OMICS , 2019 , Article)Abstract Background: Nephropathy is a common complication of type 2 diabetes mellitus (T2DM). Previous studies revealed that T2DM patients with nephropathy have higher concentrations of urinary Vitamin D Binding ... -
Association between Genetic Variants of GC Gene at 4q13.3 and Vitamin D Concentrations in Adult Females
( Longdom , 2019 , Article)Background: Vitamin D binding protein, encoded by the GC gene (on 4q13.3), plays an important role in transporting vitamin D. Several Genome-Wide Association Studies (GWASs) have established a significant association ... -
Neutrophil Gelatinase Associated Lipocalin: Is not an Early Marker Inductor for Diabetic Nephropathy in Qatari Population
( BJSTR , 2019 , Article)Background: The WHO Global Report on Diabetes (2016) showed that the number of diabetic patients quadrupled between 1980 and 2016, while causing the death of 1.5 million people. While the global prevalence of diabetes ...