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AuthorGatalica, Zoran
AuthorKuzmova, Nataliya
AuthorRose, Inga
AuthorUlamec, Monika
AuthorPeric Balja, Melita
AuthorSkenderi, Faruk
AuthorVranić, Semir
Available date2023-12-26T09:04:37Z
Publication Date2023-10-02
Publication NameBiomolecules and Biomedicine
Identifier10.17305/bb.2023.9868
CitationGatalica, Z., Kuzmova, N., Rose, I., Ulamec, M., Peric Balja, M., Skenderi, F., & Vranić, S. (2023). The assessment of tumor-infiltrating lymphocytes in invasive apocrine carcinoma of the breast in relation to the HER2 status. Biomolecules & biomedicine, 10.17305/bb.2023.9868. Advance online publication. https://doi.org/10.17305/bb.2023.9868
ISSN2831-0896
URIhttp://hdl.handle.net/10576/50634
AbstractIn the current study, we assessed the prevalence and molecular features of HER2-low phenotype in the apocrine carcinomas of the breast (ApoCa) and its relationship with tumor-infiltrating lymphocytes (TILs). A cohort of 64 well-characterized therapy-naïve ApoCa was used. The TIL distribution was assessed using the hematoxylin and eosin whole slide/scanned images following the international TILs working group recommendations. Next-generation sequencing (NGS) was performed in a subset of HER2-low ApoCa. All patients were women, with a mean age of 62 years. Forty-three carcinomas were pure apocrine carcinoma (PAC; ER-/AR+), and the remaining 21 were classified as apocrine-like carcinomas (ALCs; ER+/-, AR+/-). HER2/neu was positive (score 3+ by IHC and/or amplified by FISH) in 20/43 (47%) PAC and 4/21 (19%) ALC. The prevalence of HER2-low expression (scores 1+ or 2+ without HER2 amplification) in ApoCa was 39% without significant differences between PAC and ALC (P = 0.14); however, the HER2-low phenotype was more prevalent in triple-negative PAC than in ALC (P < 0.001). Levels of TILs were low (≤10%) in 74% of ApoCa (median 5%, range 0%-50%). TIL levels were significantly higher in ALC than in PAC (P = 0.02). HER2 status had no impact on TIL distribution (P = 0.45). The genomic profile of HER2-low ApoCa was similar to other subtypes of ApoCa. ApoCa has predominantly low TIL, particularly PAC. The prevalence of the HER2-low phenotype in ApoCa is high, which should have therapeutic and clinical implications given the recently approved therapies with antibody-drug conjugates (ADCs) for HER2-low breast cancers.
Languageen
PublisherAssociation of Basic Medical Sciences of Federation of Bosnia and Herzegovina
SubjectBreast cancer
special types
apocrine carcinoma
tumor-infiltrating lymphocytes (TILs)
HER2-low
TitleThe assessment of tumor-infiltrating lymphocytes in invasive apocrine carcinoma of the breast in relation to the HER2 status.
TypeArticle
ESSN2831-090X
dc.accessType Open Access


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