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المؤلفKohil, Amira
المؤلفAbdalla, Wafa
المؤلفIbrahim, Wisam N.
المؤلفAl-Harbi, Khalid M.
المؤلفAl-Haidose, Amal
المؤلفAl-Asmakh, Maha
المؤلفAbdallah, Atiyeh M.
تاريخ الإتاحة2023-12-28T05:14:42Z
تاريخ النشر2023
اسم المنشورMedicina (Lithuania)
المصدرScopus
الرقم المعياري الدولي للكتاب1010660X
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/medicina59091629
معرّف المصادر الموحدhttp://hdl.handle.net/10576/50641
الملخصRheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30-45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment.
راعي المشروعThis publication was supported by Qatar University, internal grant no. QUCP-CHS-2022-551 and QU Health cluster, Qatar University. The findings achieved herein are solely the responsibility of the authors.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعautoimmunity
bystander activation
epitope spreading
immunomodulation
microbiota
molecular mimicry
rheumatic heart disease
العنوانThe Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
النوعArticle Review
رقم العدد9
رقم المجلد59
dc.accessType Open Access


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