Show simple item record

AuthorKohil, Amira
AuthorAbdalla, Wafa
AuthorIbrahim, Wisam N.
AuthorAl-Harbi, Khalid M.
AuthorAl-Haidose, Amal
AuthorAl-Asmakh, Maha
AuthorAbdallah, Atiyeh M.
Available date2023-12-28T05:14:42Z
Publication Date2023
Publication NameMedicina (Lithuania)
ResourceScopus
ISSN1010660X
URIhttp://dx.doi.org/10.3390/medicina59091629
URIhttp://hdl.handle.net/10576/50641
AbstractRheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30-45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment.
SponsorThis publication was supported by Qatar University, internal grant no. QUCP-CHS-2022-551 and QU Health cluster, Qatar University. The findings achieved herein are solely the responsibility of the authors.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectautoimmunity
bystander activation
epitope spreading
immunomodulation
microbiota
molecular mimicry
rheumatic heart disease
TitleThe Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
TypeArticle Review
Issue Number9
Volume Number59
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record