The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
| Author | Kohil, Amira |
| Author | Abdalla, Wafa |
| Author | Ibrahim, Wisam N. |
| Author | Al-Harbi, Khalid M. |
| Author | Al-Haidose, Amal |
| Author | Al-Asmakh, Maha |
| Author | Abdallah, Atiyeh M. |
| Available date | 2023-12-28T05:14:42Z |
| Publication Date | 2023 |
| Publication Name | Medicina (Lithuania) |
| Resource | Scopus |
| ISSN | 1010660X |
| Abstract | Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30-45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment. |
| Sponsor | This publication was supported by Qatar University, internal grant no. QUCP-CHS-2022-551 and QU Health cluster, Qatar University. The findings achieved herein are solely the responsibility of the authors. |
| Language | en |
| Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| Subject | autoimmunity bystander activation epitope spreading immunomodulation microbiota molecular mimicry rheumatic heart disease |
| Type | Article Review |
| Issue Number | 9 |
| Volume Number | 59 |
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Biomedical Research Center Research [740 items ]
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Biomedical Sciences [739 items ]