عرض بسيط للتسجيلة

المؤلفMahmoud, Mai A.
المؤلفAyoub, Houssein H.
المؤلفCoyle, Peter
المؤلفTang, Patrick
المؤلفHasan, Mohammad R.
المؤلفYassine, Hadi M.
المؤلفAl Thani, Asmaa A.
المؤلفAl-Kanaani, Zaina
المؤلفAl-Kuwari, Einas
المؤلفJeremijenko, Andrew
المؤلفKaleeckal, Anvar Hassan
المؤلفLatif, Ali Nizar
المؤلفShaik, Riyazuddin Mohammad
المؤلفAbdul-Rahim, Hanan F.
المؤلفNasrallah, Gheyath K.
المؤلفAl-Kuwari, Mohamed Ghaith
المؤلفButt, Adeel A.
المؤلفAl-Romaihi, Hamad Eid
المؤلفAl-Thani, Mohamed H.
المؤلفAl-Khal, Abdullatif
المؤلفBertollini, Roberto
المؤلفAbu-Raddad, Laith J.
المؤلفChemaitelly, Hiam
تاريخ الإتاحة2024-01-15T05:33:08Z
تاريخ النشر2023-11-01
اسم المنشورInfluenza and other Respiratory Viruses
المعرّفhttp://dx.doi.org/10.1111/irv.13224
الاقتباسMahmoud MA, Ayoub HH, Coyle P, et al. SARS-CoV-2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study. Influenza Other Respi Viruses. 2023; 17(11):e13224. doi:10.1111/irv.13224
الرقم المعياري الدولي للكتاب17502640
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85177578949&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/50713
الملخصBackground: We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and of severe, critical, or fatal COVID-19 in older adults since pandemic onset. Methods: A national retrospective cohort study was conducted in the population of Qatar aged ≥50 years between February 5, 2020 and June 15, 2023. Adjusted hazard ratios (AHRs) for infection and for severe coronavirus disease 2019 (COVID-19) outcomes were estimated through Cox regression models. Results: Cumulative incidence was 25.01% (95% confidence interval [CI]: 24.86–25.15%) for infection and 1.59% (95% CI: 1.55–1.64%) for severe, critical, or fatal COVID-19 after a follow-up duration of 40.9 months. Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. Risk of infection was reduced with primary-series vaccination (AHR: 0.91, 95% CI: 0.90–0.93) and further with first booster vaccination (AHR: 0.75, 95% CI: 0.74–0.77). Risk of severe, critical, or fatal COVID-19 increased exponentially with age and linearly with coexisting conditions. AHRs for severe, critical, or fatal COVID-19 were 0.86 (95% CI: 0.7–0.97) for one dose, 0.15 (95% CI: 0.13–0.17) for primary-series vaccination, and 0.11 (95% CI: 0.08–0.14) for first booster vaccination. Sensitivity analysis restricted to only Qataris yielded similar results. Conclusion: Incidence of severe COVID-19 in older adults followed a dynamic pattern shaped by infection incidence, variant severity, and population immunity. Age, sex, and coexisting conditions were strong determinants of infection severity. Vaccine protection against severe outcomes showed a dose–response relationship, highlighting the importance of booster vaccination for older adults.
راعي المشروعWe acknowledge the many dedicated individuals at Hamad Medical Corporation, the Ministry of Public Health, the Primary Health Care Corporation, Qatar Biobank, Sidra Medicine, and Weill Cornell Medicine-Qatar for their diligent efforts and contributions to make this study possible. The authors are grateful for institutional salary support from the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, as well as for institutional salary support provided by the Ministry of Public Health, Hamad Medical Corporation, and Sidra Medicine. The authors are also grateful for the Qatar Genome Programme and Qatar University Biomedical Research Center for institutional support for the reagents needed for the viral genome sequencing. HHA acknowledges the support of Qatar University Internal Grant ID QUCG-CAS-23/24-114. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the article. Statements made herein are solely the responsibility of the authors.
اللغةen
الناشرWiley
الموضوعCOVID-19
geriatrics
immunity
older adults
Qatar
vaccination
العنوانSARS-CoV-2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study
النوعArticle
رقم العدد11
رقم المجلد17
ESSN1750-2659
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة