Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells
المؤلف | Queenie, Fernandes |
المؤلف | Therachiyil, Lubna |
المؤلف | Khan, Abdul Q. |
المؤلف | Bedhiafi, Takwa |
المؤلف | Korashy, Hesham M |
المؤلف | Bhat, Ajaz A. |
المؤلف | Uddin, Shahab |
تاريخ الإتاحة | 2024-01-29T11:01:03Z |
تاريخ النشر | 2023-09-19 |
اسم المنشور | European Journal of Pharmaceutical Sciences |
المعرّف | http://dx.doi.org/10.1016/j.ejps.2023.106586 |
الاقتباس | Fernandes, Q., Therachiyil, L., Khan, A. Q., Bedhiafi, T., Korashy, H. M., Bhat, A. A., & Uddin, S. (2023). Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells. European Journal of Pharmaceutical Sciences, 106586. |
الرقم المعياري الدولي للكتاب | 0928-0987 |
الملخص | Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials to engineer innovative, targeted therapies. Specifically, manipulating nanomaterials allows for enhanced drug loading efficiency, improved bioavailability, and targeted delivery systems, reducing the non-specific cytotoxic effects characteristic of conventional chemotherapies. Furthermore, recent advances in nanotechnology have demonstrated encouraging results in specifically targeting CSCs, a key development considering the role of these cells in disease recurrence and resistance to treatment. Despite these breakthroughs, the clinical approval rates of nano-drugs have not kept pace with research advances, pointing to existing obstacles that must be addressed. In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways. |
راعي المشروع | Open access is provided by Qatar National Library. |
اللغة | en |
الناشر | Elsevier |
الموضوع | Nanotherapy Cancer stem cells Signaling pathways Pharmacokinetics Drug resistance |
النوع | Article |
رقم المجلد | 191 |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
ESSN | 1879-0720 |
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