Show simple item record

AuthorMohammed I., Danjuma
AuthorSayed, Rana
AuthorAboughalia, Maryam
AuthorHassona, Aseel
AuthorElsayed, Basant Selim
AuthorElshafei, Mohamed
AuthorElzouki, Abdelnaser
Available date2024-02-14T06:02:40Z
Publication Date2023-09-16
Publication NameHeliyon
Identifierhttp://dx.doi.org/10.1016/j.heliyon.2023.e20155
CitationDanjuma, M. I., Sayed, R., Aboughalia, M., Hassona, A., Elsayed, B. S., Elshafei, M., & Elzouki, A. (2023). Does colchicine reduce mortality in patients with COVID-19 clinical syndrome? An umbrella review of published meta-analyses. Heliyon.
ISSN2405-8440
URIhttps://www.sciencedirect.com/science/article/pii/S2405844023073632
URIhttp://hdl.handle.net/10576/51788
AbstractBackgroundDespite significant improvements in both treatment and prevention strategies, as well as multiple commissioned reviews, there remains uncertainty regarding the survival benefit of repurposed drugs such as colchicine in patients with Coronavirus Disease 2019 (COVID-19) clinical syndrome. MethodsIn this umbrella review, we carried out a comprehensive search of PubMed, EMBASE, Cochrane Database of Systematic Reviews, Science Citation Index, and the Database of Abstracts of Reviews of Effectiveness between January 1, 2020 and January 31, 2023 for systematic reviews and meta-analyses evaluating the mortality-reducing benefits of colchicine in patients with COVID-19. This was to ascertain the exact relationship between colchicine exposure and mortality outcomes in these cohorts of patients. We utilized A Measurement Tool to Assess systematic Reviews-2 (AMSTAR-2) to conduct an exhaustive methodological quality and risk of bias assessment of the included reviews. ResultsWe included eighteen meta-analyses (n = 199,932 participants) in this umbrella review. Colchicine exposure was associated with an overall reduction of about 32% in the risk of mortality (odds ratio 0.68, confidence interval [CI] 0.58–0.78; I2 = 94%, p = 0.001). Further examination of pooled estimates of mortality outcomes by the quality effects model (corrected for the methodological quality and risk of bias of the constituent reviews) reported similar point estimates (OR 0.73; CI 0.59 to 0.91; I2 = 94%). ConclusionIn a pooled umbrella evaluation of published meta-analyses of COVID-19 patient cohorts, exposure to colchicine was associated with a reduction in overall mortality. Although it remains uncertain if this effect could potentially be attenuated or augmented by COVID-19 vaccination.
SponsorOpen Access funding provided by the Qatar National Library.
Languageen
PublisherElsevier
SubjectCOVID-19
Colchicine
Meta-analysis
Mortality
Umbrella
TitleDoes colchicine reduce mortality in patients with COVID-19 clinical syndrome? An umbrella review of published meta-analyses
TypeArticle
Issue Number10
Volume Number9
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN2405-8440
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record