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AuthorMohamed, Mouhand F.H.
AuthorSiepmann, Timo
AuthorSuwileh, Salah
AuthorMohammed, Mohammed H.
AuthorMohamed, Samreen
AuthorAbdalla, Lina O.
AuthorElzouki, Abdel Naser
AuthorMahmoud, Mohamed H.
AuthorAl-Mohanadi, Dabia
AuthorDanjuma, Mohammed
Available date2024-02-15T07:17:07Z
Publication Date2020-06-26
Publication NameMedicine (United States)
Identifierhttp://dx.doi.org/10.1097/MD.0000000000020778
CitationMohamed, M. F., Siepmann, T., Suwileh, S., Mohammed, M. H., Mohamed, S., Abdalla, L. O., ... & Danjuma, M. (2020). Myxedema psychosis: a protocol for a systematic review and a pooled analysis. Medicine, 99(26).
ISSN0025-7974
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087320712&origin=inward
URIhttp://hdl.handle.net/10576/51847
AbstractBackground: Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability to identify and manage this entity properly. Hence, we aimed to systematically review the literature and summarize the presentation, diagnosis, management, and outcomes of this rare entity. Methods: Systematic review following PRISMA guidance. We will perform a comprehensive search of PubMed, Medline, Embase, Google Scholar (first 300 hits), and Cochrane databases for published observational studies, case series, and case reports. We will use descriptive statistics to provide summary estimates of demographics, common presenting features, laboratory test results, imaging findings, treatment administered, and outcomes. Moreover, continuous variables will be compared by the Wilcoxon Mann Whitney test, whereas categorical variables will be assessed by the χ2 test. Bivariate and multivariate regression will be performed to assess risk factors associated with poor outcome. A scoping review revealed that a meta-analysis might not be feasible owing to the paucity of systematic studies describing the condition. Results: This is the first systematic review examining this rare entity. Thus, the result of which will be significant. We hope that this review will help in identifying relevant predictive clinical or laboratory characteristics. Additionally, it identifies the best treatment strategies. The findings of this review will help increase our knowledge of this condition so as to recognize this condition promptly. Also, it will assist in differentiating MP from masqueraders, such as Hashimoto encephalopathy (HE). The results of this review will be published in a peer-reviewed journal. Conclusion: This is the first systematic review exploring MP demographics, diagnosis treatment, and outcomes. The information gathered by this review will be necessary for patients, clinicians, researchers, and guideline makers. PROSPERO registration number: CRD42020160310.
SponsorOpen-access publication fees were supported by the Qatar National Library.
Languageen
PublisherWolters Kluwer Health
Subjecthypothyroidism
madness
myxedema
psychosis
systematic review
TitleMyxedema psychosis: A protocol for a systematic review and a pooled analysis
TypeArticle
Issue Number26
Volume Number99
ESSN1536-5964
dc.accessType Open Access


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